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  Slow clearance gadolinium-based extracellular and intravascular contrast media for three-dimensional MR angiography

Bremerich, J., Colet, J., Giovenzana, G., Aime, S., Scheffler, K., Laurent, S., et al. (2001). Slow clearance gadolinium-based extracellular and intravascular contrast media for three-dimensional MR angiography. Journal of Magnetic Resonance Imaging, 13(4), 588-593. doi:10.1002/jmri.1082.

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Bremerich, J, Author
Colet, JM, Author
Giovenzana , GB, Author
Aime, S, Author
Scheffler, K1, Author           
Laurent, S, Author
Bongartz, G, Author
Muller, RN, Author
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1External Organizations, ou_persistent22              

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 Abstract: The objective of this study was to assess two new slow-clearance contrast media with extracellular and intravascular distribution for magnetic resonance angiography (MRA). Extracellular Gd-DTPA-BC2glucA and intravascular Gd(DO3A)3-lys16 were developed within the European Biomed2 MACE Program and compared with two reference compounds, intravascular CMD-A2-Gd-DOTA and extracellular GdDOTA, in 12 rats. Pre- and post-contrast three-dimensional MR (TR/TE = 5 msec/2.2 msec; isotropic voxel size 0.86 mm3) was acquired for 2 hours. Signal-to-noise enhancement (ΔSNR) was calculated. Two minutes after injection, all contrast media provided strong vascular signal enhancement. The ΔSNR for Gd-DTPA-BC2glucA, Gd(DO3A)3-lys16, CMD-A2-Gd-DOTA, and GdDOTA were 13.0 ± 1.8, 25.0 ± 3.2, 25.0 ± 4.0, and 18.0 ± 3.4, respectively. Gd-DTPA-BC2glucA, Gd(DO3A)3-lys16, and CMD-A2-Gd-DOTA cleared slowly from the circulation, whereas GdDOTA cleared rapidly. Vascular ΔSNR at 2 hours were 2.9 ± 0.6, 25.0 ± 3.2, 25.0 ± 4.0, and 0.4 ± 1.0. Gd(DO3A)3-lys16 provided strong vascular and minor background enhancement, and thus may be useful for MRA or perfusion imaging. Gd-DTPA-BC2glucA produces persistent enhancement of extracellular water, and thus may allow quantification of extracellular distribution volume and assessment of myocardial viability.

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 Dates: 2001-04
 Publication Status: Published in print
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 Identifiers: DOI: 10.1002/jmri.1082
BibTex Citekey: BremerichCGASLBM2001
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Title: Journal of Magnetic Resonance Imaging
Source Genre: Journal
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Publ. Info: Chicago, IL : Society for Magnetic Resonance Imaging
Pages: - Volume / Issue: 13 (4) Sequence Number: - Start / End Page: 588 - 593 Identifier: ISSN: 1053-1807
CoNE: https://pure.mpg.de/cone/journals/resource/954925594512