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  Drosophila Pax-6/eyeless is essential for normal adult brain structure and function.

Callaerts, P., Leng, S., Clements, J., Cribbs, D., Kang, Y., Walldorf, U., et al. (2001). Drosophila Pax-6/eyeless is essential for normal adult brain structure and function. Journal of Neurobiology, 46(2), 73-88. doi:10.1002/1097-4695(20010205)46:2%3C73:AID-NEU10%3E3.0.CO;2-N.

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Callaerts, P, Author
Leng, S1, 2, Author              
Clements, J, Author
Cribbs, D, Author
Kang, YY, Author
Walldorf, U, Author
Fischbach, KF, Author
Strauss, R1, 2, Author              
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Former Department Neurophysiology of Insect Behavior, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497802              

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 Abstract: A role for the Pax-6 homologue eyeless in adult Drosophila brain development and function is described. eyeless expression is detected in neurons, but not glial cells, of the mushroom bodies, the medullar cortex, the lateral horn, and the pars intercerebralis. Furthermore, severe defects in adult brain structures essential for vision, olfaction, and for the coordination of locomotion are provoked by two newly isolated mutations of Pax-6/eyeless that result in truncated proteins. Consistent with the morphological lesions, we observe defective walking behavior for these eyeless mutants. The implications of these data for understanding postembryonic brain development and function in Drosophila are discussed.

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 Dates: 2001-02
 Publication Status: Published in print
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 Rev. Type: -
 Identifiers: BibTex Citekey: 33
DOI: 10.1002/1097-4695(20010205)46:2%3C73::AID-NEU10%3E3.0.CO;2-N
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Title: Journal of Neurobiology
  Other : J. Neurobiol.
Source Genre: Journal
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Publ. Info: New York : Wiley-Interscience.
Pages: - Volume / Issue: 46 (2) Sequence Number: - Start / End Page: 73 - 88 Identifier: ISSN: 0022-3034
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000256970