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  Titration of the BOLD effect: Separation and quantitation of blood volume and oxygenation changes in the human cerebral cortex during neuronal activation and ferumoxide infusion

Scheffler, K., Bilecen, D., Haselhorst, R., & Seifritz, E. (1999). Titration of the BOLD effect: Separation and quantitation of blood volume and oxygenation changes in the human cerebral cortex during neuronal activation and ferumoxide infusion. Magnetic Resonance in Medicine, 42(5), 829-836. doi:10.1002/(SICI)1522-2594(199911)42:5<829:AID-MRM2>3.0.CO;2-6.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-E61F-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-BF6B-D
Genre: Journal Article

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Scheffler, K1, Author              
Bilecen, D, Author
Haselhorst, R, Author
Seifritz, E, Author
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1External Organizations, ou_persistent22              

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 Abstract: Most functional magnetic resonance imaging (fMRI) techniques are sensitive to susceptibility variations and rely on the change in blood oxygenation level in response to neuronal activation (BOLD). The BOLD effect is accompanied by a change in cerebral blood flow (rCBF) and cerebral blood volume (rCBV). Intravascular contrast agents, such as magnetite nanoparticles, can be used to measure changes in rCBV. A new measuring protocol has been developed that enables the separate quantification of changes in blood volume and oxygenation levels. A combination of alternating acoustic stimulation blocks and infusion of a superparamagnetic contrast agent offers the possibility to disentangle the competing influences of oxygenation and blood volume changes. Serial blood sampling during infusion was used to assess the actual contrast agent concentration during infusion in order to calculate absolute blood volume changes during neuronal resting and activation states.

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 Dates: 1999-11
 Publication Status: Published in print
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 Identifiers: DOI: 10.1002/(SICI)1522-2594(199911)42:5<829::AID-MRM2>3.0.CO;2-6
BibTex Citekey: SchefflerBHS1999
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Title: Magnetic Resonance in Medicine
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 42 (5) Sequence Number: - Start / End Page: 829 - 836 Identifier: ISSN: 0740-3194
CoNE: https://pure.mpg.de/cone/journals/resource/954925538149