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  Functional MR imaging of the prefrontal cortex: specific activation in a working memory task.

Kammer, T., Bellemann, M., Glückel, F., Brix, G., Gass, A., Schlemmer, H., et al. (1997). Functional MR imaging of the prefrontal cortex: specific activation in a working memory task. Magnetic Resonance Imaging, 15(8), 879-889. doi:10.1016/S0730-725X(97)00021-0.

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Kammer, T1, 2, 3, Author              
Bellemann, ME, Author
Glückel, F, Author
Brix, G, Author
Gass, A, Author
Schlemmer, H, Author
Spitzer, M, Author
Affiliations:
1Department Human Perception, Cognition and Action, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497797              
2Former Department Comparative Neurobiology, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497800              
3Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: Functional magnetic resonance imaging was used to identify cortical regions activated by a working memory task involving letter detection, Twenty four normal subjects were scanned with a conventional 1,5-T magnet while performing one of two tasks: In the activation task, subjects responded by pressing a button whenever any presented letter was the same as the second last in the sequence, In the control condition, subjects had to respond to a single predefined letter without memory update requirements, The activation task and the control condition were identical with regard to perceptual input and motor output, They were different only regarding the task demand. Movement artifacts were minimized in a two way strategy and eight subjects were excluded from further analysis. Functional MR data from the remaining 16 subjects were analyzed on the basis of anatomical regions-of-interest which were manually defined in each subject, The engagement of working memory produced significant activation in the dorsolateral prefrontal cortex (Brodmann's areas 9, 10, 46, and 47) in both hemispheres, Results demonstrate the applicability of the paradigm within a clinical MRI setup and corroborate previous findings of non-lateralized dorsolateral prefrontal activation during continuous context updating and active maintenance. (C) 1997 Elsevier Science Inc.

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 Dates: 1997-09
 Publication Status: Published in print
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 Rev. Type: -
 Identifiers: BibTex Citekey: 365
DOI: 10.1016/S0730-725X(97)00021-0
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Title: Magnetic Resonance Imaging
Source Genre: Journal
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Publ. Info: New York : Elsevier
Pages: - Volume / Issue: 15 (8) Sequence Number: - Start / End Page: 879 - 889 Identifier: ISSN: 0730-725X
CoNE: https://pure.mpg.de/cone/journals/resource/954925533026