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  Neuroblast ablation in Drosophila P[GAL4] lines reveals origins of olfactory interneurons

Stocker, R., Heimbeck, G., Gendre, N., & de Belle, J. (1997). Neuroblast ablation in Drosophila P[GAL4] lines reveals origins of olfactory interneurons. Journal of Neurobiology, 32(5), 443-456. doi:10.1002/(SICI)1097-4695(199705)32:5<443:AID-NEU1>3.0.CO;2-5.

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Stocker, RF, Author
Heimbeck, G, Author
Gendre, N, Author
de Belle, JS1, 2, Author              
Affiliations:
1Former Department Neurophysiology of Insect Behavior, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497802              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: Hydroxyurea (HU) treatment of early first instar larvae in Drosophila was previously shown to ablate a single dividing lateral neuroblast (LNb) in the brain. Early larval HU application to p[GAL4] strains that label specific neuron types enabled us to identify the origins of the two major classes of interneurons in the olfactory system. HU treatment resulted in the loss of antennal lobe local interneurons and of a subset of relay interneurons (RI), elements usually projecting to the calyx and the lateral protocerebrum (LPR). Other RI were resistant to HU and still projected to the ERR. However, they formed no collaterals in the calyx region (which was also ablated), suggesting that their survival does not depend on targets in the calyx. Hence, the ablated interneurons were derived from the LNb, whereas the HU-resistant elements originated from neuroblasts which begin to divide later in larval life. Developmental GAL4 expression patterns suggested that differentiated RI are present at the larval state already and may be retained through metamorphosis. (C) 1997 John Wiley Sons, Inc.

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 Dates: 1997-04
 Publication Status: Published in print
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 Identifiers: BibTex Citekey: 380
DOI: 10.1002/(SICI)1097-4695(199705)32:5<443::AID-NEU1>3.0.CO;2-5
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Title: Journal of Neurobiology
  Other : J. Neurobiol.
Source Genre: Journal
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Publ. Info: New York : Wiley-Interscience.
Pages: - Volume / Issue: 32 (5) Sequence Number: - Start / End Page: 443 - 456 Identifier: ISSN: 0022-3034
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000256970