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  Dopaminergic modulation of semantic network activation

Kischka, U., Kammer, T., Weisbrod M, Maier S, Thimm, M., & Spitzer, M. (1996). Dopaminergic modulation of semantic network activation. Neuropsychologia, 34, 1107-1113.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-EBE8-7 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-EBE9-5
Genre: Journal Article

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Kischka, U, Author
Kammer, T1, 2, Author              
Weisbrod M, Maier S, Thimm, M, Author
Spitzer, M, Author
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1Department Human Perception, Cognition and Action, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497797              
2Former Department Comparative Neurobiology, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497800              

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 Abstract: In order to examine the effect of dopamine on semantic processing, we performed a double-blind, placebo-controlled study. Healthy volunteers (n = 31) were tested in a lexical decision paradigm after ingestion of either L-dopa 100 mg with benserazide 25 mg or placebo. While direct semantic priming was influenced only marginally by L-dopa, the indirect priming effect was reduced significantly. These data support the hypothesis that dopamine increases the signal-to-noise ratio in semantic networks by reducing the spread of semantic processing, thereby leading to a focussing of activation. Copyright (C) 1996 Elsevier Science Ltd.

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 Dates: 1996
 Publication Status: Published in print
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 Identifiers: BibTex Citekey: 950
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Title: Neuropsychologia
Source Genre: Journal
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Pages: - Volume / Issue: 34 Sequence Number: - Start / End Page: 1107 - 1113 Identifier: -