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  Genetic, neuroanatomical and behavioral analyses of the mushroom-body-miniature gene in Drosophila melanogaster

de Belle, J., & Heisenberg, M. (1994). Genetic, neuroanatomical and behavioral analyses of the mushroom-body-miniature gene in Drosophila melanogaster. Poster presented at Fifth European Meeting on the Neurogenetics of Drosophila, Montpellier, France.

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de Belle, JS1, 2, Author              
Heisenberg, M, Author              
Affiliations:
1Former Department Neurophysiology of Insect Behavior, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497802              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: mushroom-body-miniature (mbm) is one of ten genes identified in mass histology screens for mushroom body (MB) structural mutants (Heisenberg and Boehl, 1979.2. Narurforsch. 34C. 143). Although mbm is an autoso- ma1 gene (2-0.0 21B8-Cb). mutants exhibit a striking sexual dimorphism: MBs of females are nearly, if not completely absent, while those of males are reduced by about 30 percent. Reductions in associative odor learn- ing have been shown previously to be correlated with the severity of MB derangement or reduction, in both ge- netic dissection and tissue-specific ablation studies (Heisenberg et al., 1985. J. Neurogener. 2, l; de Belle and Heisenberg, 1993. J. Neurogenef. 8,225; de Belle and Heisenberg, 1994, Science 263,692). The sexual dimor- phism of mbrn closely follows this pattern. Here we report on a series of experiments in which we compare the anatomy and behaviour of mbm mutants in their original genetic background and in controlled genetic back- grounds derived from the wild type Cunron-S (CS). We find almost completely wild type MBs (at the level of the light microscope) in both mbm males and fe- males in CS genetic backgrounds (mbm (CS) and mbm; CS). Substitution of the X-chromosome from the origi- nal mbm stock revives the sexually dimorphic mutant structural phenotype. However. all mbrn mutants are impared in associative odor learning and memory. Only mbm (CSJ performs normally in sensory acuity control tests. We are currently carrying out experiments to characterize the heritable factors influencing mbm pheno- types, examining mbm anatomy in the genetic backgrounds of GAL4 MB-specific markers, and studying mbm behavior in additional learning and locomotor paradigms. We suggest that mbm is part of a system of genes that functions both during MB development and in the processing of sensory information during the establishment of memory.

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 Dates: 1996-01
 Publication Status: Published in print
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 Rev. Type: -
 Identifiers: BibTex Citekey: 567
DOI: 10.3109/01677069509083456
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Title: Fifth European Meeting on the Neurogenetics of Drosophila
Place of Event: Montpellier, France
Start-/End Date: 1994-10-03 - 1994-10-06

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Title: Journal of Neurogenetics
  Other : J. Neurogenet.
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 10 (1) Sequence Number: - Start / End Page: 24 Identifier: ISSN: 0167-7063
CoNE: https://pure.mpg.de/cone/journals/resource/954925483672