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  Altered serum IgG levels to α-synuclein in dementia with Lewy bodies and Alzheimer’s disease.

Koehler, N. K. U., Stransky, E., Shing, M., Gaertner, S., Meyer, M., Schreitmüller, B., et al. (2013). Altered serum IgG levels to α-synuclein in dementia with Lewy bodies and Alzheimer’s disease. PLoS One, e64649. doi:10.1371/journal.pone.0064649.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-F531-E Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-C7EF-7
Genre: Journal Article

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Koehler , N. K. U., Author
Stransky, E., Author
Shing, M., Author
Gaertner, S., Author
Meyer, M., Author
Schreitmüller, B., Author
Leyhe, T., Author
Laske, C., Author
Maetzler, W., Author
Kahle, P., Author
Celej, M. S.1, Author              
Jovin, T. M.1, Author              
Fallgatter, A. J., Author
Batra, A., Author
Buchkremer, G., Author
Schott, K., Author
Richartz-Salzburger, E., Author
Affiliations:
1Emeritus Group Laboratory of Cellular Dynamics, MPI for Biophysical Chemistry, Max Planck Society, ou_578629              

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 Abstract: Natural self-reactive antibodies in the peripheral blood may play a considerable role in the control of potentially toxic proteins that may otherwise accumulate in the aging brain. The significance of serum antibodies reactive against α-synuclein is not well known. We explored serum IgG levels to monomeric α-synuclein in dementia with Lewy bodies (DLB) and Alzheimer’s disease (AD) with a novel and validated highly sensitive ELISA assay. Antibody levels revealed stark differences in patients compared to healthy subjects and were dependent on diagnosis, disease duration and age. Anti-α-synuclein IgG levels were increased in both patient groups, but in early DLB to a much greater extent than in AD. Increased antibody levels were most evident in younger patients, while with advanced age relatively low levels were observed, similar to healthy individuals, exhibiting stable antibody levels independent of age. Our data show the presence of differentially altered IgG levels against α-synuclein in DLB and AD, which may relate to a disturbed α-synuclein homeostasis triggered by the disease process. These observations may foster the development of novel, possibly preclinical biomarkers and immunotherapeutic strategies that target α-synuclein in neurodegenerative disease.

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Language(s): eng - English
 Dates: 2013-05-31
 Publication Status: Published online
 Pages: 7
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1371/journal.pone.0064649
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Title: PLoS One
Source Genre: Journal
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Pages: - Volume / Issue: - Sequence Number: e64649 Start / End Page: - Identifier: -