English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  β2 integrin–derived signals induce cell survival and proliferation of AML blasts by activating a Syk/STAT signaling axis.

Oellerich, T., Oellerich, M. F., Engelke, M., Münch, S., Mohr, S., Nimz, M., et al. (2013). β2 integrin–derived signals induce cell survival and proliferation of AML blasts by activating a Syk/STAT signaling axis. Blood, 121(19), 3889-3899. doi:10.1182/blood-2012-09-457887.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-F537-2 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-C7E6-A
Genre: Journal Article

Files

show Files
hide Files
:
1795935-Suppl-1.pdf (Supplementary material), 10MB
Name:
1795935-Suppl-1.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
1795935-Suppl-2.xls (Supplementary material), 42KB
Name:
1795935-Suppl-2.xls
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/vnd.ms-excel / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
1795935-Suppl-3.xls (Supplementary material), 2MB
Name:
1795935-Suppl-3.xls
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/vnd.ms-excel / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Oellerich, T., Author
Oellerich , M. F., Author
Engelke, M., Author
Münch, S., Author
Mohr, S., Author
Nimz, M., Author
Hsiao, He H.1, Author              
Corso, J.1, Author              
Zhang, J., Author
Bohnenberger, H., Author
Berg, T., Author
Rieger, M. A., Author
Wienands, J., Author
Bug, G., Author
Brandts, C., Author
Urlaub, H.1, Author              
Serve, H., Author
Affiliations:
1Research Group of Bioanalytical Mass Spectrometry, MPI for biophysical chemistry, Max Planck Society, ou_578613              

Content

show
hide
Free keywords: -
 Abstract: Spleen tyrosine kinase (Syk) induces cell survival and proliferation in a high proportion of acute myeloid leukemia (AML) blasts, but the underlying molecular events of Syk signaling have not been investigated. Proteomic techniques have allowed us to identify the multiprotein complex that is nucleated by constitutively active Syk in AML cells. This complex differs from the B-lymphoid Syk interactome with respect to several proteins, especially the integrin receptor Mac-1, the Fc-γ receptor I (FcγRI), and the transcription factors STAT3 and STAT5. We show in several AML cell line models that tonic signals derived from the Fc-γ chain lead to Syk-dependent activation of STAT3 and STAT5, which in turn induces cell survival and proliferation. Moreover, stimulation of Mac-1 or FcγRI intensifies the constitutive Syk-mediated STAT3/5 activation in AML cells, a scenario likely to take place in the bone marrow niche. In accordance with these findings, we observed that β2 integrins, including Mac-1, trigger proliferation of AML cells in an AML cell/stroma coculture model. Taken together, we identified an oncogenic integrin/Syk/STAT3/5 signaling axis that might serve as a therapeutic target of AML in the future.

Details

show
hide
Language(s): eng - English
 Dates: 2013-03-182013-05-09
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1182/blood-2012-09-457887
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Blood
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 121 (19) Sequence Number: - Start / End Page: 3889 - 3899 Identifier: -