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  miR-155 regulates differentiation of brown and beige adipocytes via a bistable circuit

Chen, Y., Siegel, F., Kipschull, S., Haas, B., Froehlich, H., Meister, G., et al. (2013). miR-155 regulates differentiation of brown and beige adipocytes via a bistable circuit. NATURE COMMUNICATIONS, 4: 1769. doi:10.1038/ncomms2742.

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 Creators:
Chen, Yong1, Author
Siegel, Franziska1, Author
Kipschull, Stefanie1, Author
Haas, Bodo1, Author
Froehlich, Holger1, Author
Meister, Gunter2, Author              
Pfeifer, Alexander1, Author
Affiliations:
1external, ou_persistent22              
2Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565145              

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Free keywords: ACTIVATED RECEPTOR-GAMMA; C/EBP-BETA; ADIPOSE-TISSUE; TRANSCRIPTIONAL CONTROL; FAT DIFFERENTIATION; MITOCHONDRIAL BIOGENESIS; LENTIVIRAL VECTORS; GENE-EXPRESSION; STEM-CELLS; MICRORNA-155
 Abstract: Brown adipocytes are a primary site of energy expenditure and reside not only in classical brown adipose tissue but can also be found in white adipose tissue. Here we show that microRNA 155 is enriched in brown adipose tissue and is highly expressed in proliferating brown preadipocytes but declines after induction of differentiation. Interestingly, microRNA 155 and its target, the adipogenic transcription factor CCAAT/enhancer-binding protein beta, form a bistable feedback loop integrating hormonal signals that regulate proliferation or differentiation. Inhibition of microRNA 155 enhances brown adipocyte differentiation and induces a brown adipocyte-like phenotype ('browning') in white adipocytes. Consequently, microRNA 155-deficient mice exhibit increased brown adipose tissue function and 'browning' of white fat tissue. In contrast, transgenic overexpression of microRNA 155 in mice causes a reduction of brown adipose tissue mass and impairment of brown adipose tissue function. These data demonstrate that the bistable loop involving microRNA 155 and CCAAT/enhancer-binding protein b regulates brown lineage commitment, thereby, controlling the development of brown and beige fat cells.

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Language(s): eng - English
 Dates: 2013-04-23
 Publication Status: Published online
 Pages: 13
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: ISI: 000318872100126
DOI: 10.1038/ncomms2742
 Degree: -

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Title: NATURE COMMUNICATIONS
Source Genre: Journal
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Publ. Info: MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND : NATURE PUBLISHING GROUP
Pages: - Volume / Issue: 4 Sequence Number: 1769 Start / End Page: - Identifier: ISSN: 2041-1723