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  Disparity between dorsal and ventral networks in patients with obsessive-compulsive disorder: Evidence revealed by graph theoretical analysis based on cortical thickness from MRI

Kim, S.-G., Jung, W. H., Kim, S. N., Jang, J. H., & Kwon, J. S. (2013). Disparity between dorsal and ventral networks in patients with obsessive-compulsive disorder: Evidence revealed by graph theoretical analysis based on cortical thickness from MRI. Frontiers in Human Neuroscience, 7: 302. doi:10.3389/fnhum.2013.00302.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-F902-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-84E3-7
Genre: Journal Article

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 Creators:
Kim, Seung-Goo1, 2, Author              
Jung, Wi Hoon3, Author
Kim, Sung Nyun4, Author
Jang, Joon Hwan4, Author
Kwon, Jun Soo1, 3, 4, Author
Affiliations:
1Department of Brain and Cognitive Sciences, Seoul National University Seoul, South Korea, ou_persistent22              
2Methods and Development Unit Cortical Networks and Cognitive Functions, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634557              
3Clinical Cognitive Neuroscience Center, SNU-MRC, Seoul National University Hospital Seoul, South Korea, ou_persistent22              
4Department of Psychiatry, College of Medicine, Seoul National University Seoul, South Korea, ou_persistent22              

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Free keywords: dorsal-ventral imbalance
 Abstract: As one of the most widely accepted neuroanatomical models on obsessive-compulsive disorder (OCD), it has been hypothesized that imbalance between an excitatory direct (ventral) pathway and an inhibitory indirect (dorsal) pathway in cortico-striato-thalamic circuit underlies the emergence of OCD. Here we examine the structural network in drug-free patients with OCD in terms of graph theoretical measures for the first time. We used a measure called efficiency which quantifies how a node transfers information efficiently. To construct brain networks, cortical thickness was automatically estimated using T1-weighted magnetic resonance imaging. We found that the network of the OCD patients was as efficient as that of healthy controls so that the both networks were in the small-world regime. More importantly, however, disparity between the dorsal and the ventral networks in the OCD patients was found in terms of graph theoretical measures, suggesting a positive evidence to the imbalance theory on the underlying pathophysiology of OCD.

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Language(s): eng - English
 Dates: 2013-01-272013-06-032013-07-03
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: PMC: 3699763
PMID: 23840184
DOI: 10.3389/fnhum.2013.00302
Other: eCollection 2013
 Degree: -

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Title: Frontiers in Human Neuroscience
  Abbreviation : Front Hum Neurosci
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 7 Sequence Number: 302 Start / End Page: - Identifier: ISSN: 1662-5161
CoNE: https://pure.mpg.de/cone/journals/resource/1662-5161