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  Epicoccolides: Antimicrobial and antifungal polyketides from an endophytic fungus Epicoccum sp associated with Theobroma cacao.

Talontsi, F. M., Dittrich, B., Schüffler, A., Sun, H., & Laatsch, H. (2013). Epicoccolides: Antimicrobial and antifungal polyketides from an endophytic fungus Epicoccum sp associated with Theobroma cacao. European Journal of Organic Chemistry, (15), 3174-3180. doi:10.1002/ejoc.201300146.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-F802-F Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-C7F0-1
Genre: Journal Article

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1798410.pdf (Publisher version), 489KB
 
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 Creators:
Talontsi, F. M., Author
Dittrich, B., Author
Schüffler, A., Author
Sun, H.1, Author              
Laatsch, H., Author
Affiliations:
1Department of NMR based Structural Biology, MPI for biophysical chemistry, Max Planck Society, ou_578567              

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Free keywords: Natural products; Antimicrobial agents; Antifungal agents; Polyketides; Structure elucidation
 Abstract: In the search for new compounds to protect plants from fungi, an endophytic fungus, Epicoccum sp. CAFTBO, obtained from Theobroma cacao was found to produce three polyoxygenated polyketides, namely epicolactone (1) and epicoccolides A (2) and B (3), together with seven known metabolites. The structures of these compounds were elucidated by a combination of detailed spectroscopic and spectrometric analyses as well as DFT calculations of the electronic circular dichroism spectra and the single-crystal X-ray diffraction analysis of 1. Compounds 1-3 showed potent antimicrobial activities and significant inhibitory effects on the mycelial growth of two peronosporomycete phytopathogens, Pythium ultimum and Aphanomyces cochlioides, and the basidiomycetous fungus Rhizoctonia solani.

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Language(s): eng - English
 Dates: 2013-04-092013-05
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1002/ejoc.201300146
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Title: European Journal of Organic Chemistry
Source Genre: Journal
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Pages: - Volume / Issue: (15) Sequence Number: - Start / End Page: 3174 - 3180 Identifier: -