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  A novel frontal pathway underlies verbal fluency in primary progressive aphasia

Catani, M., Mesulam, M. M., Jakobsen, E., Malik, F., Matersteck, A., Wieneke, C., et al. (2013). A novel frontal pathway underlies verbal fluency in primary progressive aphasia. Brain, 136(8), 2619-2628. doi:10.1093/brain/awt163.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-FA2C-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-8427-C
Genre: Journal Article

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 Creators:
Catani, Marco1, Author
Mesulam, Marsel M2, 3, Author
Jakobsen, Estrid1, Author              
Malik, Farah1, Author
Matersteck, Adam2, Author
Wieneke, Christina2, Author
Thompson, Cynthia K2, Author
Thiebaut de Schotten, Michel1, 4, Author
Dell'Acqua, Flavio1, 5, 6, Author
Weintraub, Sandra7, Author
Rogalski, Emily2, Author
Affiliations:
1Natbrainlab, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, United Kingdom, ou_persistent22              
2Cognitive Neurology and Alzheimer’s Disease Centre, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA, ou_persistent22              
3Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA, ou_persistent22              
4Centre de Recherche de l’institut du Cerveau et de la Moelle épinière, Université Pierre et Marie Curie-Paris VI, Paris, France, ou_persistent22              
5Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, United Kingdom, ou_persistent22              
6NIHR Maudsley Biomedical Research Centre, King’s College London, United Kingdom, ou_persistent22              
7Departments of Psychiatry and Behavioural Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA, ou_persistent22              

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Free keywords: Aphasia; White matter; Language; Tractography; Dementia; Freesurfer; Frontal aslant tract; Tractography
 Abstract: The frontal aslant tract is a direct pathway connecting Broca’s region with the anterior cingulate and pre-supplementary motor area. This tract is left lateralized in right-handed subjects, suggesting a possible role in language. However, there are no previous studies that have reported an involvement of this tract in language disorders. In this study we used diffusion tractography to define the anatomy of the frontal aslant tract in relation to verbal fluency and grammar impairment in primary progressive aphasia. Thirty-five patients with primary progressive aphasia and 29 control subjects were recruited. Tractography was used to obtain indirect indices of microstructural organization of the frontal aslant tract. In addition, tractography analysis of the uncinate fasciculus, a tract associated with semantic processing deficits, was performed. Damage to the frontal aslant tract correlated with performance in verbal fluency as assessed by the Cinderella story test. Conversely, damage to the uncinate fasciculus correlated with deficits in semantic processing as assessed by the Peabody Picture Vocabulary Test. Neither tract correlated with grammatical or repetition deficits. Significant group differences were found in the frontal aslant tract of patients with the non-fluent/agrammatic variant and in the uncinate fasciculus of patients with the semantic variant. These findings indicate that degeneration of the frontal aslant tract underlies verbal fluency deficits in primary progressive aphasia and further confirm the role of the uncinate fasciculus in semantic processing. The lack of correlation between damage to the frontal aslant tract and grammar deficits suggests that verbal fluency and grammar processing rely on distinct anatomical networks.

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Language(s): eng - English
 Dates: 2012-12-192013-04-292013-07-022013-08-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1093/brain/awt163
PMID: 23820597
PMC: PMC3722349
Other: Epub 2013
 Degree: -

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Title: Brain
  Other : Brain
Source Genre: Journal
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Affiliations:
Publ. Info: London : Macmillan
Pages: - Volume / Issue: 136 (8) Sequence Number: - Start / End Page: 2619 - 2628 Identifier: ISSN: 0006-8950
CoNE: https://pure.mpg.de/cone/journals/resource/954925385135