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Free keywords:
CARBON-HYDROGEN BONDS; MOLECULAR-OXYGEN; AUTOXIDATION; OXIDATION; CHEMISTRY; PHOTOOXYGENATION; NUCLEOPHILES; ALKYLATION; PEROXIDES; INDOLES
Abstract:
A Brønsted acid catalyzed C–H functionalization via Intermediate PeroxideS (CHIPS), generated photochemically, allows the oxidative coupling of indole derivatives with a variety of nitrogen nucleophiles. The reaction can be performed in one pot and requires only visible light, elemental oxygen, a Brønsted acid and a photosensitizer. The method can be applied to an efficient synthesis of some biologically active compounds.