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  The MAP1 family of microtubule-associated proteins

Halpain, S., & Dehmelt, L. (2006). The MAP1 family of microtubule-associated proteins. Genome Biology, 7(6): 1, pp. 224.1-224.7. Retrieved from http://genomebiology.com/2006/7/6/224.

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 Creators:
Halpain, Shelley, Author
Dehmelt, Leif1, Author           
Affiliations:
1Abt. II: Systemische Zellbiologie, Max Planck Institute of Molecular Physiology, Max Planck Society, ou_1753288              

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Free keywords: Animals; Evolution, Molecular; Gene Expression Regulation; Humans; Microtubule-Associated Proteins/chemistry/genetics/*physiology; Models, Genetic; Morphogenesis; Nerve Tissue Proteins/chemistry/genetics/*physiology; Nervous System/*metabolism; Phylogeny
 Abstract: MAP1-family proteins are classical microtubule-associated proteins (MAPs) that bind along the microtubule lattice. The founding members, MAP1A and MAP1B, are predominantly expressed in neurons, where they are thought to be important in the formation and development of axons and dendrites. Mammalian genomes usually contain three family members, MAP1A, MAP1B and a shorter, more recently identified gene called MAP1S. By contrast, only one family member, Futsch, is found in Drosophila. After their initial expression, the MAP1A and MAP1B polypeptides are cleaved into light and heavy chains, which are then assembled into mature complexes together with the separately encoded light chain 3 subunit (LC3). Both MAP1A and MAP1B are well known for their microtubule-stabilizing activity, but MAP1 proteins can also interact with other cellular components, including filamentous actin and signaling proteins. Furthermore, the activity of MAP1A and MAP1B is controlled by upstream signaling mechanisms, including the MAP kinase and glycogen synthase kinase-3 beta pathways.

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Language(s): eng - English
 Dates: 2006-06-30
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 411009
URI: http://genomebiology.com/2006/7/6/224
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Title: Genome Biology
Source Genre: Journal
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Pages: - Volume / Issue: 7 (6) Sequence Number: 1 Start / End Page: 224.1 - 224.7 Identifier: ISSN: 1465-6914 (Electronic)