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  Natural product guided compound library development

Breinbauer, R., Manger, M., Scheck, M., & Waldmann, H. (2002). Natural product guided compound library development. Current Medicinal Chemistry, 9(23): 1, pp. 2129-2145.

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Genre: Journal Article
Alternative Title : Curr. Med. Chem.

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currmedchem-9-2129.pdf (Any fulltext), 11MB
 
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 Creators:
Breinbauer, Rolf1, Author           
Manger, Michael2, Author
Scheck, Michael2, Author
Waldmann, Herbert1, Author           
Affiliations:
1Abt. IV: Chemische Biologie, Max Planck Institute of Molecular Physiology, Max Planck Society, ou_1753290              
2Max Planck Institute of Molecular Physiology, Max Planck Society, ou_1753286              

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Free keywords: combinatorial chemistry; drug discovery; lead optimisation; natural products; organic synthesis; protein domains; solid phase synthesis
 Abstract: Natural products are biologically validated starting points for the design of combinatorial libraries, as they have a proven record of biological relevance. This special role of natural products in medicinal chemistry and chemical biology can be interpreted in the light of new insights about the domain architecture of proteins gained by structural biology and bioinformatics. In order to fulfil the specific requirements of the individual binding pocket within a domain family it is necessary to optimise the natural product structure by chemical variation. Solid-phase chemistry is becoming an efficient tool for this optimisation process, and recent advances in this field are highlighted in this review article.

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Language(s): eng - English
 Dates: 2002-12
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 6069
 Degree: -

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Title: Current Medicinal Chemistry
  Alternative Title : Curr. Med. Chem.
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 9 (23) Sequence Number: 1 Start / End Page: 2129 - 2145 Identifier: -