Chemo-enzymatic synthesis of the C₁₅-C₂₃ unit of leptomycin B

Scheck, Michael; Waldmann, Herbert

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Chemo-enzymatic synthesis of the C₁₅-C₂₃ unit of leptomycin B

Scheck, M., & Waldmann, H. (2002). Chemo-enzymatic synthesis of the C₁₅-C₂₃ unit of leptomycin B. Canadian Journal of Chemistry - Revue Canadienne de Chimie, 80(6): 1, pp. 571-576. Retrieved from http://article.pubs.nrc-cnrc.gc.ca/ppv/RPViewDoc?_handler_=HandleInitialGet&journal=cjc&volume=80&calyLang=eng&articleFile=v02-070.pdf.

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Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-0014-0E78-F Versions-Permalink: https://hdl.handle.net/11858/00-001M-0000-0014-0E79-D

Genre: Zeitschriftenartikel

Alternativer Titel : Can. J. Chem. - Rev. Can. Chim.

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Urheber:
Scheck, Michael¹, Autor
Waldmann, Herbert², Autor

Affiliations:
1Max Planck Institute of Molecular Physiology, Max Planck Society, ou_1753286
2Abt. IV: Chemische Biologie, Max Planck Institute of Molecular Physiology, Max Planck Society, ou_1753290

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Schlagwörter: leptomycin; natural product synthesis; enzymatic transformation; Aldol reaction; Pseudomonas fluorescence lipase (PFL)

Zusammenfassung: The asymmetric synthesis of the C-15-C-23 unit of Leptomycin B (LMB) is described. All four stereocenters of the C-15-C-23 unit were prepared from one building block exhibiting only one stereocenter. This building block was synthesized via either an enzymatic transformation or starting from a chiral reagent.