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  Transient association of titin and myosin with microtubules in nascent myofibrils directed by the MURF2 RING-finger protein

Pizon, V., Iakovenko, A., van der Ven, P. F. M., Kelly, R., Fatu, C., Fürst, D. O., Karsenti, E., & Gautel, M. (2002). Transient association of titin and myosin with microtubules in nascent myofibrils directed by the MURF2 RING-finger protein. Journal of Cell Science, 115(23), 4469-4482. Retrieved from http://dx.doi.org/10.1242/jcs.00131.

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アイテムのパーマリンク: https://hdl.handle.net/11858/00-001M-0000-0014-0F36-C 版のパーマリンク: https://hdl.handle.net/11858/00-001M-0000-0014-0F37-A
資料種別: 学術論文
その他のタイトル : J. Cell Sci.

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 作成者:
Pizon, Véronique, 著者
Iakovenko, Andrei1, 著者
van der Ven, Peter F. M., 著者
Kelly, Raymond1, 著者
Fatu, Cristina1, 著者
Fürst, Dieter O., 著者
Karsenti, Eric, 著者
Gautel, Mathias, 著者
所属:
1Max Planck Institute of Molecular Physiology, Max Planck Society, ou_1753286              

内容説明

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キーワード: myosin; microtubules; titin; MURF2; myofibril; assembly; connectin
 要旨: Assembly of muscle sarcomeres is a complex dynamic process and involves a large number of proteins. A growing number of these have regulatory functions and are transiently present in the myofibril. We show here that the novel tubulin-associated RING/B-box protein MURF2 associates transiently with microtubules, myosin and titin during sarcomere assembly. During sarcomere assembly, MURF2 first associates with microtubules at the exclusion of tyrosinated tubulin. Then, MURF2-labelled microtubules associate transiently with sarcomeric myosin and later with A-band titin when non-striated myofibrils differentiate into mature sarcomeres. Finally, MURF2 labelled microtubules disappear from the sarcomere after the incorporation of myosin filaments and the elongation of titin. This suggests that the incorporation of myosin into nascent sarcomeres and the elongation of titin require an active, microtubule-dependent transport process and that MURF2- associated microtubules play a role in the alignment and extension of nascent sarcomeres. MURF2 is expressed in at least four isoforms, of which a 27 kDa isoform is cardiac specific. A C-terminal isoform is generated by alternative reading frame use, a novelty in muscle proteins. In mature cardiac sarcomeres, endogenous MURF2 can associate with the M-band, and is translocated to the nucleus. MURF2 can therefore act as a transient adaptor between microtubules, titin and nascent myosin filaments, as well as being involved in signalling from the sarcomere to the nucleus.

資料詳細

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言語: eng - English
 日付: 2002
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: 査読あり
 識別子（DOI, ISBNなど）: eDoc: 10854
URI: http://dx.doi.org/10.1242/jcs.00131
 学位: -

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出版物 1

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出版物名: Journal of Cell Science
  出版物の別名 : J. Cell Sci.
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: -
ページ: - 巻号: 115 (23) 通巻号: - 開始・終了ページ: 4469 - 4482 識別子（ISBN, ISSN, DOIなど）: -