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  JUNGBRUNNEN1, a reactive oxygen species-responsive NAC transcription factor, regulates longevity in Arabidopsis

Wu, A., Allu, A. D., Garapati, P., Siddiqui, H., Dortay, H., Zanor, M. I., et al. (2012). JUNGBRUNNEN1, a reactive oxygen species-responsive NAC transcription factor, regulates longevity in Arabidopsis. The Plant Cell, 24(2), 482-506. doi:10.​1105/​tpc.​111.​090894.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-1E59-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-834C-0
Genre: Journal Article

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 Creators:
Wu, A.1, Author              
Allu, A. D.1, Author              
Garapati, P.1, Author              
Siddiqui, H.2, Author
Dortay, H.2, Author
Zanor, M. I.3, Author              
Asensi-Fabado, M. A.2, Author
Munne-Bosch, S.2, Author
Antonio, C.3, Author              
Tohge, T.3, Author              
Fernie, A. R.3, Author              
Kaufmann, K.2, Author
Xue, G. P.2, Author
Mueller-Roeber, B.4, Author              
Balazadeh, S.1, Author              
Affiliations:
1Transcription Factors and Gene Regulatory Networks, Cooperative Research Groups, Max Planck Institute of Molecular Plant Physiology, Max Planck Society, ou_1753316              
2External Organizations, ou_persistent22              
3Central Metabolism, Department Willmitzer, Max Planck Institute of Molecular Plant Physiology, Max Planck Society, ou_1753339              
4Plant Signalling, Cooperative Research Groups, Max Planck Institute of Molecular Plant Physiology, Max Planck Society, ou_1753311              

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 Abstract: The transition from juvenility through maturation to senescence is a complex process that involves the regulation of longevity. Here, we identify JUNGBRUNNEN1 (JUB1), a hydrogen peroxide (H(2)O(2))-induced NAC transcription factor, as a central longevity regulator in Arabidopsis thaliana. JUB1 overexpression strongly delays senescence, dampens intracellular H(2)O(2) levels, and enhances tolerance to various abiotic stresses, whereas in jub1-1 knockdown plants, precocious senescence and lowered abiotic stress tolerance are observed. A JUB1 binding site containing a RRYGCCGT core sequence is present in the promoter of DREB2A, which plays an important role in abiotic stress responses. JUB1 transactivates DREB2A expression in mesophyll cell protoplasts and transgenic plants and binds directly to the DREB2A promoter. Transcriptome profiling of JUB1 overexpressors revealed elevated expression of several reactive oxygen species-responsive genes, including heat shock protein and glutathione S-transferase genes, whose expression is further induced by H(2)O(2) treatment. Metabolite profiling identified elevated Pro and trehalose levels in JUB1 overexpressors, in accordance with their enhanced abiotic stress tolerance. We suggest that JUB1 constitutes a central regulator of a finely tuned control system that modulates cellular H(2)O(2) level and primes the plants for upcoming stress through a gene regulatory network that involves DREB2A.

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Language(s): eng - English
 Dates: 2012-02-222012
 Publication Status: Published in print
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Title: The Plant Cell
  Abbreviation : Plant C
Source Genre: Journal
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Publ. Info: Rockville : American Society of Plant Physiologists
Pages: - Volume / Issue: 24 (2) Sequence Number: - Start / End Page: 482 - 506 Identifier: Other: 1532-298X
CoNE: https://pure.mpg.de/cone/journals/resource/1532-298X