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  F2C2: a fast tool for the computation of flux coupling in genome-scale metabolic networks

Larhlimi, A., David, L., Selbig, J., & Bockmayr, A. (2012). F2C2: a fast tool for the computation of flux coupling in genome-scale metabolic networks. Bmc Bioinformatics, 13, 57. doi:10.1186/10.1186/1471-2105-13-57.

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Larhlimi, A.1, Author              
David, L.2, Author
Selbig, J.1, Author              
Bockmayr, A.2, Author
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1BioinformaticsCRG, Cooperative Research Groups, Max Planck Institute of Molecular Plant Physiology, Max Planck Society, ou_1753315              
2External Organizations, ou_persistent22              

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Free keywords: yeast metabolism balance analysis reconstruction models constraints evolution pathways
 Abstract: Background: Flux coupling analysis (FCA) has become a useful tool in the constraint-based analysis of genome-scale metabolic networks. FCA allows detecting dependencies between reaction fluxes of metabolic networks at steady-state. On the one hand, this can help in the curation of reconstructed metabolic networks by verifying whether the coupling between reactions is in agreement with the experimental findings. On the other hand, FCA can aid in defining intervention strategies to knock out target reactions. Results: We present a new method F2C2 for FCA, which is orders of magnitude faster than previous approaches. As a consequence, FCA of genome-scale metabolic networks can now be performed in a routine manner. Conclusions: We propose F2C2 as a fast tool for the computation of flux coupling in genome-scale metabolic networks. F2C2 is freely available for non-commercial use at https://sourceforge.net/projects/f2c2/files/.

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Language(s): eng - English
 Dates: 2012
 Publication Status: Published in print
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 Identifiers: ISI: ISI:000311931100001
DOI: 10.1186/10.1186/1471-2105-13-57
ISSN: 1471-2105
URI: ://000311931100001 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515416/pdf/1471-2105-13-57.pdf
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Title: Bmc Bioinformatics
Source Genre: Journal
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Pages: - Volume / Issue: 13 Sequence Number: - Start / End Page: 57 Identifier: -