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  Rapid metabolic evolution in human prefrontal cortex

Fu, X., Giavalisco, P., Liu, X. L., Catchpole, G., Fu, N., Ning, Z. B., et al. (2011). Rapid metabolic evolution in human prefrontal cortex. Proceedings of the National Academy of Sciences of the United States of America, 108(15), 6181-6186. doi:10.1073/pnas.1019164108.

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 Creators:
Fu, X.1, Author
Giavalisco, P.2, Author              
Liu, X. L.1, Author
Catchpole, G.3, Author              
Fu, N.1, Author
Ning, Z. B.1, Author
Guo, S.1, Author
Yan, Z.1, Author
Somel, M.1, Author
Paabo, S.1, Author
Zeng, R.1, Author
Willmitzer, L.3, Author              
Khaitovich, P.1, Author
Affiliations:
1External Organizations, ou_persistent22              
2Experimental Systems Biology, Department Willmitzer, Max Planck Institute of Molecular Plant Physiology, Max Planck Society, ou_1753342              
3Small Molecules, Department Willmitzer, Max Planck Institute of Molecular Plant Physiology, Max Planck Society, ou_1753340              

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Free keywords: cognition glutamate development magnetic-resonance spectroscopy gene-expression neurotransmitter flux gas-chromatography postmortem changes life-history human brain rat-brain glutamate primate
 Abstract: Human evolution is characterized by the rapid expansion of brain size and drastic increase in cognitive capabilities. It has long been suggested that these changes were accompanied by modifications of brain metabolism. Indeed, human-specific changes on gene expression or amino acid sequence were reported for a number of metabolic genes, but actual metabolite measurements in humans and apes have remained scarce. Here, we investigate concentrations of more than 100 metabolites in the prefrontal and cerebellar cortex in 49 humans, 11 chimpanzees, and 45 rhesus macaques of different ages using gas chromatography-mass spectrometry (GC-MS). We show that the brain metabolome undergoes substantial changes, both ontogenetically and evolutionarily: 88% of detected metabolites show significant concentration changes with age, whereas 77% of these metabolic changes differ significantly among species. Although overall metabolic divergence reflects phylogenetic relationships among species, we found a fourfold acceleration of metabolic changes in prefrontal cortex compared with cerebellum in the human lineage. These human-specific metabolic changes are paralleled by changes in expression patterns of the corresponding enzymes, and affect pathways involved in synaptic transmission, memory, and learning.

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Language(s): eng - English
 Dates: 2011-03-282011
 Publication Status: Published in print
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 Identifiers: ISI: ISI:000289413600052
DOI: 10.1073/pnas.1019164108
ISSN: 0027-8424
URI: ://000289413600052http://www.pnas.org/content/108/15/6181.full.pdf
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Title: Proceedings of the National Academy of Sciences of the United States of America
  Other : Proc. Natl. Acad. Sci. U. S. A.
Source Genre: Journal
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Publ. Info: National Academy of Sciences
Pages: - Volume / Issue: 108 (15) Sequence Number: - Start / End Page: 6181 - 6186 Identifier: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230