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  Transcription factors relevant to auxin signalling coordinate broad-spectrum metabolic shifts including sulphur metabolism

Falkenberg, B., Witt, I., Zanor, M. I., Steinhauser, D., Mueller-Roeber, B., Hesse, H., et al. (2008). Transcription factors relevant to auxin signalling coordinate broad-spectrum metabolic shifts including sulphur metabolism. Journal of Experimental Botany, 59(10), 2831-2846. doi:10.1093/jxb/ern144.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-27B2-7 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-0623-4
Genre: Journal Article

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 Creators:
Falkenberg, B.1, Author              
Witt, I.2, Author
Zanor, M. I.3, Author              
Steinhauser, D.4, 5, Author              
Mueller-Roeber, B.3, Author              
Hesse, H.1, Author              
Hoefgen, R.1, Author              
Affiliations:
1Amino Acid and Sulfur Metabolism, Department Willmitzer, Max Planck Institute of Molecular Plant Physiology, Max Planck Society, ou_1753337              
2External Organizations, ou_persistent22              
3Plant Signalling, Cooperative Research Groups, Max Planck Institute of Molecular Plant Physiology, Max Planck Society, ou_1753311              
4Small Molecules, Department Willmitzer, Max Planck Institute of Molecular Plant Physiology, Max Planck Society, ou_1753340              
5Systems Metabolomics, Department Willmitzer, Max Planck Institute of Molecular Plant Physiology, Max Planck Society, Am Mühlenberg 1, 14476 Potsdam-Golm, DE, ou_1797285              

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Free keywords: auxin sulphur metabolism systems biology transcription factors transgenic potato plants bacterial serine acetyltransferase arabidopsis-thaliana aux/iaa proteins methionine biosynthesis nitrogen assimilation regulatory networks response factors amino-acids gene
 Abstract: A systems approach has previously been used to follow the response behaviour of Arabidopsis thaliana plants upon sulphur limitation. A response network was reconstructed from a time series of transcript and metabolite profiles, integrating complex metabolic and transcript data in order to investigate a potential causal relationship. The resulting scale-free network allowed potential transcriptional regulators of sulphur metabolism to be identified. Here, three sulphur-starvation responsive transcription factors, IAA13, IAA28, and ARF-2 (ARF1-(B) under bar inding (P) under bar rotein), all of which are related to auxin signalling, were selected for further investigation. IAA28 overexpressing and knock-down lines showed no major morphological changes, whereas IAA13- and ARF1-BP-overexpressing plants grew more slowly than the wild type. Steady-state metabolite levels and expression of pathway-relevant genes were monitored under normal and sulphate-depleted conditions. For all lines, changes in transcript and metabolite levels were observed, yet none of these changes could exclusively be linked to sulphur stress. Instead, up- or down-regulation of the transcription factors caused metabolic changes which in turn affected sulphur metabolism. Auxin-relevant transcription factors are thus part of a complex response pattern to nutrient starvation that serve as coordinators of the metabolic shifts driving sulphur homeostasis rather then as direct effectors of the sulphate assimilation pathway. This study provides the first evidence ever presented that correlates auxin-related transcriptional regulators with primary plant metabolism.

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Language(s): eng - English
 Dates: 2008-07-042008
 Publication Status: Published in print
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 Identifiers: ISI: ISI:000257401500022
DOI: 10.1093/jxb/ern144
ISSN: 1460-2431 (Electronic)0022-0957 (Linking)
URI: ://000257401500022http://jxb.oxfordjournals.org/content/59/10/2831.full.pdf
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Title: Journal of Experimental Botany
Source Genre: Journal
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Pages: - Volume / Issue: 59 (10) Sequence Number: - Start / End Page: 2831 - 2846 Identifier: -