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  Statistical methods for comparing comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry results: Metabolomic analysis of mouse tissue extracts

Shellie, R. A., Welthagen, W., Zrostlikova, J., Spranger, J., Ristow, M., Fiehn, O., et al. (2005). Statistical methods for comparing comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry results: Metabolomic analysis of mouse tissue extracts. In 2nd International Symposium on Comprehensive Multidimensional Gas Chromatography (pp. 83-90).

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Shellie-2005-Statistical methods.pdf (Any fulltext), 369KB
 
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Shellie, R. A.1, Author
Welthagen, W.1, Author
Zrostlikova, J.1, Author
Spranger, J.1, Author
Ristow, M.1, Author
Fiehn, O.2, Author              
Zimmermann, R.1, Author
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1External Organizations, ou_persistent22              
2Metabolomic Analysis, Department Willmitzer, Max Planck Institute of Molecular Plant Physiology, Max Planck Society, ou_1753345              

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Free keywords: gas chromatography comprehensive two-dimensional mass spectrometry time-of-flight metabolomics data processing suspected allergens quantitation metabolites networks systems
 Abstract: The potential for the utilization of GC x GC-time-of-flight (TOF) MS for high-resolution metabolomics studies is discussed, with the implementation of some statistical comparisons for biomarker detection. Metabolite profiles from NZO obese mice versus BL/6 control mice are compared and contrasted using a number of chromatogram comparison routines, including direct chromatogram comparisons, chromatogram subtraction and averaging routines, as well as a method for generating relative weighted peak surface difference chromatograms, and a more conventional Student's t-test statistical approach. (c) 2005 Elsevier B.V. All rights reserved.

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Language(s): eng - English
 Dates: 2005
 Publication Status: Published in print
 Pages: -
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 Identifiers: ISI: ISI:000231185500009
DOI: 10.1016/j.chroma.2005.05.088
URI: ://000231185500009 http://ac.els-cdn.com/S0021967305011593/1-s2.0-S0021967305011593-main.pdf?_tid=19891c5c-693d-11e2-ab2f-00000aacb35f&acdnat=1359372371_c8d0b7243d5d5e2179d18cf44a6b2ee2
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Title: 2nd International Symposium on Comprehensive Multidimensional Gas Chromatography
Place of Event: Atlanta, GA
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Title: 2nd International Symposium on Comprehensive Multidimensional Gas Chromatography
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 83 - 90 Identifier: -