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  Looking beyond sugars: the role of amphiphilic solutes in preventing adventitious reactions in anhydrobiotes at low water contents

Oliver, A. E., Hincha, D. K., & Crowe, J. H. (2002). Looking beyond sugars: the role of amphiphilic solutes in preventing adventitious reactions in anhydrobiotes at low water contents. In 21st International Congress of the ESCPD (pp. 515-525).

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-2E99-3 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-2E9A-1
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 Creators:
Oliver, A. E.1, Author
Hincha, D. K.2, Author              
Crowe, J. H.1, Author
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1External Organizations, ou_persistent22              
2Transcript Profiling, Infrastructure Groups and Service Units, Max Planck Institute of Molecular Plant Physiology, Max Planck Society, ou_1753306              

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Free keywords: anhydrobiosis membrane phase state disaccharides carbohydrate glasses amphiphiles phospholipase a(2) membrane hydrolysis plant myrothamnus-flabellifolia pancreatic phospholipase a2 membrane phase-transitions free fatty-acids desiccation tolerance dry liposomes phosphatidylcholine liposomes senescent membranes molecular mobility lipid polymorphism
 Abstract: Plants and animals that can survive dehydration accumulate high concentrations of disaccharides in their cells and tissues during desiccation. These sugars are necessary both for the depression of the membrane phase transition temperature of the dry lipid and for the formation of a carbohydrate glass. In the past decade, however, it has become clear that certain types of adventitious enzymatic reactions are possible at low water contents, which along with free-radical mediated damage, can cause hydrolysis of lipids and loss of membrane barrier function. Disaccharides do not necessarily prevent these types of reactions, which suggests that other compounds might also be necessary for protecting organisms from this type of degradation during anhydrobiosis. Arbutin, one possible example, accumulates in large quantities in certain resurrection plants and has been shown to inhibit phospholipase A, activity at low water contents. The direct effect of arbutin on membranes under stress conditions depends on the membrane lipid composition. It can serve a protective function during desiccation- or freeze/thaw-induced stress in the presence of nonbilayer-forming lipids or a disruptive function in their absence. Other possible amphiphiles, including certain naturally occurring flavonols, may serve as anti-oxidants and some might have similar lipid composition-dependent effects. Such compounds, therefore, are likely to be localized near specific membranes, where they might provide the greatest benefit at the least liability to the organism. (C) 2002 Elsevier Science Inc. All rights reserved.

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Language(s): eng - English
 Dates: 2002
 Publication Status: Published in print
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 Identifiers: ISI: ISI:000174507800005
DOI: 10.1016/S1095-6433(01)00514-1
URI: ://000174507800005 http://ac.els-cdn.com/S1095643301005141/1-s2.0-S1095643301005141-main.pdf?_tid=f6081370-7114-11e2-827a-00000aacb35e&acdnat=1360234741_393888baa8aa4726bdf8fe608f39c41b
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Title: 21st International Congress of the ESCPD
Place of Event: LIEGE, BELGIUM
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Title: 21st International Congress of the ESCPD
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 515 - 525 Identifier: -