A short enantioselective synthesis of 1-deoxy-L-xylulose by antibody catalysis

Shabat, Doron; List, Benjamin; Lerner, Richard A.; Barbas III, Carlos F.

doi:10.1016/S0040-4039(98)02699-9

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A short enantioselective synthesis of 1-deoxy-L-xylulose by antibody catalysis

Shabat, D., List, B., Lerner, R. A., & Barbas III, C. F. (1999). A short enantioselective synthesis of 1-deoxy-L-xylulose by antibody catalysis. Tetrahedron Letters, 40(8), 1437-1440. doi:10.1016/S0040-4039(98)02699-9.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0014-A4F2-7 Version Permalink: https://hdl.handle.net/21.11116/0000-0007-60D7-A

Genre: Journal Article

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Creators:
Shabat, Doron¹, Author
List, Benjamin¹, Author
Lerner, Richard A.¹, Author
Barbas III, Carlos F.¹, Author

Affiliations:
1The Skaggs Institute for Chemical Biology and the Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA., ou_persistent22

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Abstract: A new efficient synthesis of 1-deoxy-l-xylulose (1) is presented. The key step is achieved by a highly enantioselective aldol addition of hydroxyacetone to benzyloxyacetaldehyde via antibody catalysis. The synthesis described here should provide a convenient route to isotopically labeled derivatives.

A two step enantioselective synthesis of 1-deoxy-L-xylulose has been achieved utilizing aldolase antibody 38C2 (Aldrich #47,995-0)

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Language(s): eng - English

Dates: Submitted: 1998-10-30Date issued: 1999-02-19

Publication Status: Issued

Pages: 4

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Rev. Type: Peer

Identifiers: DOI: 10.1016/S0040-4039(98)02699-9

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Title: Tetrahedron Letters

Abbreviation : Tetrahedron Lett.

Source Genre: Journal

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Publ. Info: Oxford : Pergamon

Pages: - Volume / Issue: 40 (8) Sequence Number: - Start / End Page: 1437 - 1440 Identifier: ISSN: 0040-4039
CoNE: https://pure.mpg.de/cone/journals/resource/954925448772