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Abstract:
With this communication we extend the methodology of proline-catalyzed direct asymmetric aldol reactions to include α-unsubstituted aldehydes as acceptors. This important aldehyde class gives the corresponding aldols in 22−77% yield and up to 95% ee when the reactions are performed in pure acetone or in ketone/chloroform mixtures. On the basis of these results we have developed a concise new synthesis of (S)-ipsenol.
