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  The evolutionarily conserved protein CG9186 is associated with lipid droplets, required for their positioning and for fat storage.

Thiel, K., Heier, C., Haberl, V., Thul, P. J., Oberer, M., Lass, A., et al. (2013). The evolutionarily conserved protein CG9186 is associated with lipid droplets, required for their positioning and for fat storage. Journal of Cell Science, 126(10), 2198-2212. doi:10.1242/jcs.120493.

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 Urheber:
Thiel, K.1, Autor           
Heier, C., Autor
Haberl, V., Autor
Thul, P. J.1, Autor           
Oberer, M., Autor
Lass, A., Autor
Jäckle, H.1, Autor           
Beller, M.1, Autor           
Affiliations:
1Department of Molecular Developmental Biology, MPI for biophysical chemistry, Max Planck Society, ou_578590              

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Schlagwörter: Lipid droplets, Organelle clustering, Organelle positioning, Lipid metabolism, Drosophila melanogaster
 Zusammenfassung: Lipid droplets (LDs) are specialized cell organelles for the storage of energy-rich lipids. Although lipid storage is a conserved feature of all cells and organisms, little is known about fundamental aspects of the cell biology of LDs, including their biogenesis, structural assembly and subcellular positioning, and the regulation of organismic energy homeostasis. We identified a novel LD-associated protein family, represented by the Drosophila protein CG9186 and its murine homolog MGI:1916082. In the absence of LDs, both proteins localize at the endoplasmic reticulum (ER). Upon lipid storage induction, they translocate to LDs using an evolutionarily conserved targeting mechanism that acts through a 60-amino-acid targeting motif in the center of the CG9186 protein. Overexpression of CG9186, and MGI: 1916082, causes clustering of LDs in both tissue culture and salivary gland cells, whereas RNAi knockdown of CG9186 results in a reduction of LDs. Organismal RNAi knockdown of CG9186 results in a reduction in lipid storage levels of the fly. The results indicate that we identified the first members of a novel and evolutionarily conserved family of lipid storage regulators, which are also required to properly position LDs within cells.

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Sprache(n): eng - English
 Datum: 2013-05-15
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1242/jcs.120493
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Titel: Journal of Cell Science
Genre der Quelle: Zeitschrift
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Seiten: - Band / Heft: 126 (10) Artikelnummer: - Start- / Endseite: 2198 - 2212 Identifikator: -