English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Functional and structural syntax networks in aging

Antonenko, D., Brauer, J., Meinzer, M., Hubert, A., Kerti, L., Friederici, A. D., et al. (2013). Functional and structural syntax networks in aging. NeuroImage, 83, 513-523. doi:10.1016/j.neuroimage.2013.07.018.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-184F-F Version Permalink: http://hdl.handle.net/21.11116/0000-0003-8414-1
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Antonenko, Daria1, Author
Brauer, Jens2, Author              
Meinzer, Marcus1, Author
Hubert, Anja2, Author              
Kerti, Lucia1, Author
Friederici, Angela D.2, 3, Author              
Flöel, Agnes1, 3, Author
Affiliations:
1NeuroCure Cluster of Excellence, Charité University Medicine Berlin, Germany, ou_persistent22              
2Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
3Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              

Content

show
hide
Free keywords: Connectivity; Functional imaging; Language; Resting-state; White matter integrity
 Abstract: Language abilities are known to deteriorate in aging, possibly related to decreased functional and structural connectivity within specialized brain networks. Here, we investigated syntactic ability in healthy young and older adults using a comprehensive assessment of behavioral performance, task-independent functional (FC) and structural brain connectivity (SC). Seed-based FC originating from left pars opercularis (part of Broca's area) known to support syntactic processes was assessed using resting-state functional magnetic resonance imaging, and SC using fractional anisotropy from diffusion weighted imaging, in the dorsally located superior longitudinal and the ventrally located uncinate fasciculi (SLF, UF) and forceps minor. Young compared to older adults exhibited superior syntactic performance and stronger FC within the mainly left-lateralized syntax network, which was beneficial for performance. In contrast, in older adults, FC within the mainly left-lateralized syntax network was reduced and did not correlate with performance; inter-hemispheric FC to right inferior frontal and angular gyri was detrimental for performance. In both groups, performance was positively correlated with inter-hemispheric SC. For intra-hemispheric SC, performance correlated with structural integrity of SLF in young adults and with integrity of UF in older adults. Our data show that reduced syntactic ability in older adults is associated with decreased FC within dedicated syntax networks. Moreover, young adults showed an association of syntactic ability with structural integrity of the dorsal tract, while older adults rely more on ventral fibers. In sum, our study provided novel insight into the relationship between connectivity and syntactic performance in young and older adults. In addition to elucidating age-related changes in syntax networks and their behavioral relevance, our results contribute to a better understanding of age-related changes in functional and structural brain organization in general, an important prerequisite for developing novel strategies to counteract age-related cognitive decline.

Details

show
hide
Language(s): eng - English
 Dates: 2013-07-062013-07-162013-12
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2013.07.018
PMID: 23867559
Other: Epub 2013
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: NeuroImage
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 83 Sequence Number: - Start / End Page: 513 - 523 Identifier: ISSN: 1053-8119
CoNE: /journals/resource/954922650166