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  Syntheses of Zindoxifene and Analogues by Titanium-Induced Oxo-Amide Coupling

Fürstner, A., Jumbam, D. N., & Seidel, G. (1994). Syntheses of Zindoxifene and Analogues by Titanium-Induced Oxo-Amide Coupling. Chemische Berichte, 127(6), 1125-1130. doi:10.1002/cber.19941270624.

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 Creators:
Fürstner, Alois1, Author              
Jumbam, Denis N.1, Author              
Seidel, Günter1, Author              
Affiliations:
1Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445584              

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Free keywords: Indoles, 2-aryl-; Titanium graphite; Zindoxifene; Tumor-growth inhibitors; Alkylidenation, intramolecular
 Abstract: Highly reactive titanium on graphite is used to reductively cyclize electron-rich acylamino carbonyl compounds 7, 8, 12, 14, and 16 to the corresponding indole derivatives 9, 10, 13, 15, and 17. Compound 9b is a known precursor of the mammary tumor-inhibiting compound zindoxifene (2). The other products are new analogues of this anticancer drug, exhibiting the substitution pattern previously recognized to be essential for high pharmacological activity.

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Language(s): eng - English
 Dates: 1994-04-012006-01-261994-06
 Publication Status: Published in print
 Pages: 6
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/cber.19941270624
 Degree: -

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Title: Chemische Berichte
  Abbreviation : Chem. Ber.
Source Genre: Journal
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Publ. Info: Weinheim/Bergsr. [etc.] : VCH Verlagsgesellschaft mbH. [etc.]
Pages: 6 Volume / Issue: 127 (6) Sequence Number: - Start / End Page: 1125 - 1130 Identifier: ISSN: 0009-2940
CoNE: https://pure.mpg.de/cone/journals/resource/954926940716