English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Common genetic variation near MC4R has a sex-specific impact on human brain structure and eating behavior

Horstmann, A., Kovacs, P., Kabisch, S., Böttcher, Y., Schlögl, H., Tönjes, A., et al. (2013). Common genetic variation near MC4R has a sex-specific impact on human brain structure and eating behavior. PLoS One, 8(9): e74362. doi:10.1371/journal.pone.0074362.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-1C51-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-849C-8
Genre: Journal Article

Files

show Files
hide Files
:
Horstmann_2013_Common.pdf (Publisher version), 2MB
Name:
Horstmann_2013_Common.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Horstmann, Annette1, 2, Author              
Kovacs, Peter2, 3, Author
Kabisch, Stefan4, Author              
Böttcher, Yvonne2, Author
Schlögl, Haiko4, Author              
Tönjes, Anke4, Author
Stumvoll, Michael2, 4, Author
Pleger, Burkhard1, 2, 5, Author              
Villringer, Arno1, 2, 5, 6, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
3Interdisciplinary Centre for Clinical Research, University of Leipzig, Germany , ou_persistent22              
4Faculty of Medicine, University of Leipzig, Germany, ou_persistent22              
5Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
6Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              

Content

show
hide
Free keywords: -
 Abstract: Obesity is associated with genetic and environmental factors but the underlying mechanisms remain poorly understood. Recent genome-wide association studies (GWAS) identified obesity- and type 2 diabetes-associated genetic variants located within or near genes that modulate brain activity and development. Among the top hits is rs17782313 near MC4R, encoding for the melanocortin-4-receptor, which is expressed in brain regions that regulate eating. Here, we hypothesized rs17782313-associated changes in human brain regions that regulate eating behavior. Therefore, we examined effects of common variants at rs17782313 near MC4R on brain structure and eating behavior. Only in female homozygous carriers of the risk allele we found significant increases of gray matter volume (GMV) in the right amygdala, a region known to influence eating behavior, and the right hippocampus, a structure crucial for memory formation and learning. Further, we found bilateral increases in medial orbitofrontal cortex, a multimodal brain structure encoding the subjective value of reinforcers, and bilateral prefrontal cortex, a higher order regulation area. There was no association between rs17782313 and brain structure in men. Moreover, among female subjects only, we observed a significant increase of ‘disinhibition’, and, more specifically, on ‘emotional eating’ scores of the Three Factor Eating Questionnaire in carriers of the variant rs17782313’s risk allele. These findings suggest that rs17782313’s effect on eating behavior is mediated by central mechanisms and that these effects are sex-specific.

Details

show
hide
Language(s): eng - English
 Dates: 2013-02-072013-08-022013-09-16
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1371/journal.pone.0074362
PMID: 24066140
PMC: PMC3774636
Other: eCollection 2013
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: PLoS One
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: San Francisco, CA : Public Library of Science
Pages: - Volume / Issue: 8 (9) Sequence Number: e74362 Start / End Page: - Identifier: ISSN: 1932-6203
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000277850