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Free keywords:
acylcyanation - α-amino nitrile - Brønsted acid catalysis - organocatalysis - acetyl cyanide
Abstract:
Aldimines react with acetyl cyanide in the presence of a catalytic amount of a thiourea catalyst to give the corresponding N-acetylated amino nitriles in high yields. The scope of the reaction is broad and both aromatic as well as aliphatic aldimines can readily be used.