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Free keywords:
acylcyanation; α-amino nitrile; Brønsted acid catalysis; organocatalysis; acetyl cyanide
Abstract:
Aldimines react with acetyl cyanide in the presence of a catalytic amount of a thiourea catalyst to give the corresponding N-acetylated amino nitriles in high yields. The scope of the reaction is broad and both aromatic as well as aliphatic aldimines can readily be used.