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  Proline‐Catalyzed Mannich Reaction of Aldehydes with N‐Boc‐Imines

Yang, J. W., Stadler, M., & List, B. (2007). Proline‐Catalyzed Mannich Reaction of Aldehydes with N‐Boc‐Imines. Angewandte Chemie International Edition, 46(4), 609-611. doi:10.1002/anie.200603188.

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 Creators:
Yang, Jung Woon1, Author              
Stadler, Michael1, Author              
List, Benjamin1, Author              
Affiliations:
1Research Department List, Max-Planck-Institut für Kohlenforschung, Max Planck Society, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, ou_1445585              

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Free keywords: amino aldehydes; asymmetric synthesis; imines; Mannich reaction; organocatalysis
 Abstract: A curious cat.: The proline‐catalyzed Mannich reaction between aldehydes and N‐Boc‐imines (Boc=tert‐butoxycarbonyl) gives crystalline β‐amino aldehydes with exceptionally high diastereoselectivities and enantioselectivities (see scheme). The products of this reaction typically precipitate from the reaction mixture and are useful intermediates in the synthesis of α‐ and β‐substituted β‐amino acids.

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Language(s): eng - English
 Dates: 2006-08-052007-01-102007-01-15
 Publication Status: Published in print
 Pages: 3
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/anie.200603188
 Degree: -

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Title: Angewandte Chemie International Edition
  Abbreviation : Angew. Chem., Int. Ed.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 46 (4) Sequence Number: - Start / End Page: 609 - 611 Identifier: ISSN: 1433-7851
CoNE: https://pure.mpg.de/cone/journals/resource/1433-7851