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  Catalytic Asymmetric Three-Component Acyl-Strecker Reaction

Pan, S. C., & List, B. (2007). Catalytic Asymmetric Three-Component Acyl-Strecker Reaction. Organic Letters, 9(6), 1149-1151. doi:10.1021/ol0702674.

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 Creators:
Pan, Subhas Chandra1, Author              
List, Benjamin1, Author              
Affiliations:
1Research Department List, Max-Planck-Institut für Kohlenforschung, Max Planck Society, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, ou_1445585              

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 Abstract: The first organocatalytic asymmetric three-component Strecker reaction, the urea-catalyzed acylcyanation of in situ generated imines, has been developed. Different α-amido nitriles are formed in excellent yields and enantioslectivities from aldehydes, amines, and acyl cyanides in the presence of Jacobsen's thiourea catalyst 5. Despite its obvious use for the synthesis of α-amino acids and their derivatives, our reaction may find use in diversity oriented synthesis and medicinal chemistry.

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Language(s): eng - English
 Dates: 2007-02-022007-02-242007-03-01
 Publication Status: Published in print
 Pages: 3
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1021/ol0702674
 Degree: -

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Title: Organic Letters
  Other : Org. Lett.
Source Genre: Journal
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Publ. Info: Washington, DC : American Chemical Society
Pages: - Volume / Issue: 9 (6) Sequence Number: - Start / End Page: 1149 - 1151 Identifier: ISSN: 1523-7060
CoNE: https://pure.mpg.de/cone/journals/resource/954925626338