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  Dynamic control of synaptic vesicle replenishment and short-term plasticity by Ca2+-Calmodulin-Munc13-1 signaling.

Lipstein, N., Sakaba, T., Cooper, B. H., Lin, K. H., Strenzke, N., Ashery, U., et al. (2013). Dynamic control of synaptic vesicle replenishment and short-term plasticity by Ca2+-Calmodulin-Munc13-1 signaling. Neuron, 79(1), 82-96. doi:10.1016/j.neuron.2013.05.011.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0014-3EA3-1 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0028-1F6A-9
Genre: Journal Article

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 Creators:
Lipstein, N., Author
Sakaba, T.1, Author           
Cooper, B. H., Author
Lin, K. H.2, Author           
Strenzke, N., Author
Ashery, U., Author
Rhee, J. S., Author
Taschenberger, H.2, Author           
Neher, E.3, Author           
Brose, N., Author
Affiliations:
1Research Group of Biophysics of Synaptic Transmission, MPI for biophysical chemistry, Max Planck Society, ou_578583              
2Research Group of Activity-Dependent and Developmental Plasticity at the Calyx of Held, MPI for biophysical chemistry, Max Planck Society, ou_578581              
3Emeritus Group of Membrane Biophysics, MPI for Biophysical Chemistry, Max Planck Society, ou_1571137              

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 Abstract: Short-term synaptic plasticity, the dynamic alteration of synaptic strength during high-frequency activity, is a fundamental characteristic of all synapses. At the calyx of Held, repetitive activity eventually results in short-term synaptic depression, which is in part due to the gradual exhaustion of releasable synaptic vesicles. This is counterbalanced by Ca2+-dependent vesicle replenishment, but the molecular mechanisms of this replenishment are largely unknown. We studied calyces of Held in knockin mice that express a Ca2+-Calmodulin insensitive Munc13-1(W464R) variant of the synaptic vesicle priming protein Munc13-1. Calyces of these mice exhibit a slower rate of synaptic vesicle replenishment, aberrant short-term depression and reduced recovery from synaptic depression after high-frequency stimulation. Our data establish Munc13-1 as a major presynaptic target of Ca2+-Calmodulin signaling and show that the Ca2+-Calmodulin-Munc13-1 complex is a pivotal component of the molecular machinery that determines short-term synaptic plasticity characteristics.

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Language(s): eng - English
 Dates: 2013-07-10
 Publication Status: Issued
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 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.neuron.2013.05.011
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Title: Neuron
Source Genre: Journal
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Pages: - Volume / Issue: 79 (1) Sequence Number: - Start / End Page: 82 - 96 Identifier: -