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  NKT Cell-TCR Expression Activates Conventional T Cells in Vivo, but Is Largely Dispensable for Mature NKT Cell Biology

Vahl, J. C., Heger, K., Knies, N., Hein, M. Y., Boon, L., Yagita, H., et al. (2013). NKT Cell-TCR Expression Activates Conventional T Cells in Vivo, but Is Largely Dispensable for Mature NKT Cell Biology. PLOS BIOLOGY, 11(6): e1001589. doi:10.1371/journal.pbio.1001589.

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 Creators:
Vahl, J. Christoph1, Author              
Heger, Klaus1, Author              
Knies, Nathalie1, Author              
Hein, Marco Y.2, Author              
Boon, Louis3, Author
Yagita, Hideo3, Author
Polic, Bojan3, Author
Schmidt-Supprian, Marc1, Author              
Affiliations:
1Schmidt-Supprian, Marc / Molecular Immunology and Signaltransduction, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565167              
2Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565159              
3external, ou_persistent22              

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Free keywords: NATURAL-KILLER-CELLS; MICROBIAL INFECTION; TRANSGENIC MICE; CUTTING EDGE; HOMEOSTASIS; ANTIGENS; INNATE; MOUSE; DIFFERENTIATION; RECOGNITION
 Abstract: Natural killer T (NKT) cell development depends on recognition of self-glycolipids via their semi-invariant V alpha 14i-TCR. However, to what extent TCR-mediated signals determine identity and function of mature NKT cells remains incompletely understood. To address this issue, we developed a mouse strain allowing conditional V alpha 14i-TCR expression from within the endogenous Tcr alpha locus. We demonstrate that naive T cells are activated upon replacement of their endogenous TCR repertoire with V alpha 14i-restricted TCRs, but they do not differentiate into NKT cells. On the other hand, induced TCR ablation on mature NKT cells did not affect their lineage identity, homeostasis, or innate rapid cytokine secretion abilities. We therefore propose that peripheral NKT cells become unresponsive to and thus are independent of their autoreactive TCR.

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Language(s): eng - English
 Dates: 2013-06
 Publication Status: Published online
 Pages: 16
 Publishing info: -
 Table of Contents: -
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Title: PLOS BIOLOGY
Source Genre: Journal
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Publ. Info: 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA : PUBLIC LIBRARY SCIENCE
Pages: - Volume / Issue: 11 (6) Sequence Number: e1001589 Start / End Page: - Identifier: ISSN: 1545-7885