ausblenden:
Schlagwörter:
alkylation; asymmetric catalysis; nucleophilic substitution; organocatalysis; transetherification
Zusammenfassung:
Bridging the gap: Brønsted acids catalyze an intramolecular SN2-type alkylation of alcohols with ethers by bridging a pentacoordinate transition state, thus simultaneously activating both the leaving group and nucleophile (see scheme). Density functional calculations provide detailed insight into the course of the reaction and the transition-state structure.
