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  Prospective slice-by-slice motion correction reduces false positive activations in fMRI with task-correlated motion

Schulz, J., Siegert, T., Bazin, P.-L., Maclaren, J., Herbst, M., Zaitsev, M., et al. (2014). Prospective slice-by-slice motion correction reduces false positive activations in fMRI with task-correlated motion. NeuroImage, 84, 124-132. doi:10.1016/j.neuroimage.2013.08.006.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-4735-E Version Permalink: http://hdl.handle.net/21.11116/0000-0003-1487-E
Genre: Journal Article

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 Creators:
Schulz, Jessica1, Author              
Siegert, Thomas1, Author              
Bazin, Pierre-Louis1, 2, Author              
Maclaren, Julian3, Author
Herbst, Michael4, Author
Zaitsev, Maxim4, Author
Turner, Robert1, Author              
Affiliations:
1Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634550              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
3Department of Radiology, Stanford University, CA, USA, ou_persistent22              
4Department of Radiology, University Medical Center, Freiburg, Germany, ou_persistent22              

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Free keywords: Optical motion tracking; Magnetic resonance imaging; Prospective motion correction; fMRI; False positive activations
 Abstract: Objective: We aimed to test the hypothesis that slice-by-slice prospective motion correction at 7 T using an optical tracking system reduces the rate of false positive activations in an fMRI group study with a paradigm that involves task-correlated motion. Materials and methods: Brain activation during right leg movement was measured using a block design on 15 volunteers, with and without prospective motion correction. Clearly erroneous activations were compared between both cases, at the individual level. Additionally, conventional group analysis was performed. Results: The number of falsely activated voxels with T-values higher than 5 was reduced by 48% using prospective motion correction alone, without additional retrospective realignment. In the group analysis, the statistical power was increased — the peak T-value was 26% greater, and the number of voxels in the cluster representing the right leg was increased by a factor of 8.3. Conclusion: Slice-by-slice prospective motion correction in fMRI studies with task-correlated motion can substantially reduce false positive activations and increase statistical power.

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Language(s): eng - English
 Dates: 2013-08-062013-08-152014-01-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2013.08.006
PMID: 23954484
Other: Epub 2013
 Degree: -

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Title: NeuroImage
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 84 Sequence Number: - Start / End Page: 124 - 132 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166