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  White-matter microstructure and language lateralization in left-handers: A whole-brain MRI analysis.

Perlaki, G., Horvath, R., Orsi, G., Aradi, M., Auer, T., Varga, E., et al. (2013). White-matter microstructure and language lateralization in left-handers: A whole-brain MRI analysis. Brain and Cognition, 82(3), 319-328. doi:10.1016/j.bandc.2013.05.005.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-4CD1-A Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-CA6E-2
Genre: Journal Article

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1835347.pdf (Publisher version), 2MB
 
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 Creators:
Perlaki, G., Author
Horvath, R., Author
Orsi, G., Author
Aradi, M., Author
Auer, T.1, Author              
Varga, E., Author
Kantor, G., Author
Altbäcker, A., Author
John, F., Author
Doczi, T., Author
Komoly, S., Author
Kovacs, N., Author
Schwarc, A., Author
Janszky, J., Author
Affiliations:
1Biomedical NMR Research GmbH, MPI for biophysical chemistry, Max Planck Society, ou_578634              

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Free keywords: Diffusion tensor imaging; Functional magnetic resonance imaging; Atypical speech laterality; Left-handers; Superior longitudinal fasciculus; Superior parietal lobe
 Abstract: Most people are left-hemisphere dominant for language. However the neuroanatomy of language lateralization is not fully understood. By combining functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI), we studied whether language lateralization is associated with cerebral white-matter (WM) microstructure. Sixteen healthy, left-handed women aged 20-25 were included in the study. Left-handers were targeted in order to increase the chances of involving subjects with atypical language lateralization. Language lateralization was determined by fMRI using a verbal fluency paradigm. Tract-based spatial statistics analysis of DTI data was applied to test for WM microstructural correlates of language lateralization across the whole brain. Fractional anisotropy and mean diffusivity were used as indicators of WM microstructural organization. Right-hemispheric language dominance was associated with reduced microstructural integrity of the left superior longitudinal fasciculus and left-sided parietal lobe WM. In left-handed women, reduced integrity of the left-sided language related tracts may be closely linked to the development of right hemispheric language dominance. Our results may offer new insights into language lateralization and structure-function relationships in human language system.

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Language(s): eng - English
 Dates: 2013-06-212013-08
 Publication Status: Published in print
 Pages: -
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 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.bandc.2013.05.005
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Title: Brain and Cognition
Source Genre: Journal
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Pages: - Volume / Issue: 82 (3) Sequence Number: - Start / End Page: 319 - 328 Identifier: ISSN: 0278-2626