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  Slice accelerated gradient-echo spin-echo dynamic susceptibility contrast imaging with blipped CAIPI for increased slice coverage

Eichner, C., Jafari-Khouzani, K., Cauley, S., Bhat, H., Polaskova, P., Andronesi, O. C., et al. (2014). Slice accelerated gradient-echo spin-echo dynamic susceptibility contrast imaging with blipped CAIPI for increased slice coverage. Magnetic Resonance in Medicine, 72(3), 770-778. doi:10.1002/mrm.24960.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-4DCC-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-B0A5-B
Genre: Journal Article

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 Creators:
Eichner, Cornelius1, Author              
Jafari-Khouzani, Kourosh 2, Author
Cauley, Stephen2, Author
Bhat, Himanshu3, Author
Polaskova, Pavlina2, Author
Andronesi, Ovidiu C.2, Author
Rapalino, Otto2, Author
Turner, Robert1, Author              
Wald, Lawrence L.2, Author
Setsompop, Kawim2, Author
Stufflebeam, Steven2, Author
Affiliations:
1Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_persistent22              
2Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA, ou_persistent22              
3Siemens Healthcare Sector, Charlestown, MA, USA, ou_persistent22              

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Free keywords: DSC; GESE; CAIPIRINHA; blipped CAIPI; SMS; Brain tumor
 Abstract: Purpose: To improve slice coverage of gradient echo spin echo (GESE) sequences for dynamic susceptibility contrast (DSC) MRI using a simultaneous-multiple-slice (SMS) method. Methods: Data were acquired on 3 Tesla (T) MR scanners with a 32-channel head coil. To evaluate use of SMS for DSC, an SMS GESE sequence with two-fold slice coverage and same temporal sampling was compared with a standard GESE sequence, both with 2× in-plane acceleration. A signal to noise ratio (SNR) comparison was performed on one healthy subject. Additionally, data with Gadolinium injection were collected on three patients with glioblastoma using both sequences, and perfusion analysis was performed on healthy tissues as well as on tumor. Results: Retained SNR of SMS DSC is 90% for a gradient echo (GE) and 99% for a spin echo (SE) acquisition, compared with a standard acquisition without slice acceleration. Comparing cerebral blood volume maps, it was observed that the results of standard and SMS acquisitions are comparable for both GE and SE images. Conclusion: Two-fold slice accelerated DSC MRI achieves similar SNR and perfusion metrics as a standard acquisition, while allowing a significant increase in slice coverage of the brain. The results also point to a possibility to improve temporal sampling rate, while retaining the same slice coverage.

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Language(s): eng - English
 Dates: 2013-08-292013-07-172013-08-302013-10-282014-09
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/mrm.24960
PMID: 24285593
PMC: PMC4002660
Other: Epub 2013
 Degree: -

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Title: Magnetic Resonance in Medicine
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 72 (3) Sequence Number: - Start / End Page: 770 - 778 Identifier: ISSN: 0740-3194
CoNE: https://pure.mpg.de/cone/journals/resource/954925538149