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  Effects of finger tapping frequency on regional homogeneity of sensorimotor cortex

Lv, Y., Margulies, D. S., Villringer, A., & Zang, Y.-F. (2013). Effects of finger tapping frequency on regional homogeneity of sensorimotor cortex. PLoS One, 8(5): e64115. doi:10.1371/journal.pone.0064115.

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© 2013 Lv et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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 Creators:
Lv, Yating1, 2, Author              
Margulies, Daniel S.3, 4, Author              
Villringer, Arno1, 4, Author              
Zang, Yu-Feng2, 5, Author
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Center for Cognition and Brain Disorders, Clinical Medicine College, Hangzhou Normal University, ou_persistent22              
3Max Planck Research Group Neuroanatomy and Connectivity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_1356546              
4Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
5State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, China, ou_persistent22              

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 Abstract: Resting-state functional magnetic resonance imaging (RS-fMRI) has been widely used to investigate temporally correlated fluctuations between distributed brain areas, as well as to characterize local synchronization of low frequency (<0.1 Hz) spontaneous fMRI signal. Regional homogeneity (ReHo) was proposed as a voxel-wise measure of the synchronization of the timecourses of neighboring voxels and has been used in many studies of brain disorders. However, the interpretation of ReHo remains challenging because the effect of high frequency task on ReHo is still not clear. In order to investigate the effect of a high-frequency task on the modulation of local synchronization of resting-state activity, we employed three right-finger movement scanning sessions: slow-event related (‘Slow’), fast-event related (‘Fast’), and continuous finger pressure (‘Tonic’), from 21 healthy participants and compared the ReHo of the three task states with that of resting-state (‘Rest’). In the contralateral sensorimotor cortex, ‘Slow’ task state showed greater ReHo than ‘Rest’ in low frequency band (0–0.08Hz) fMRI signal, but lower ReHo in high frequency band (0.08–1.67 Hz); ‘Fast’ task state showed lower ReHo than ‘Rest’ in both the low and high frequency band; ‘Tonic’ state did not show any significant difference compared to ‘Rest’. The results in the contralateral sensorimotor cortex suggest that local synchronization of BOLD signal varies with different finger tapping speed. In the ipsilateral sensorimotor cortex, all the three task states had lower ReHo than the ‘Rest’ state both in the low and high frequency, suggesting a similar effect of fast and slow finger tapping frequencies on local synchronization of BOLD signal in the ipsilateral motor cortex.

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Language(s): eng - English
 Dates: 2012-11-232013-04-092013-05-16
 Publication Status: Published online
 Pages: -
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 Rev. Type: Peer
 Identifiers: DOI: 10.1371/journal.pone.0064115
PMID: 23696867
PMC: PMC3655932
Other: Print 2013
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Title: PLoS One
Source Genre: Journal
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Publ. Info: San Francisco, CA : Public Library of Science
Pages: - Volume / Issue: 8 (5) Sequence Number: e64115 Start / End Page: - Identifier: ISSN: 1932-6203
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000277850