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  Unravelling the intrinsic functional organization of the human lateral frontal cortex: A parcellation scheme based on resting state fMRI

Goulas, A., Uylings, H. B. M., & Stiers, P. (2012). Unravelling the intrinsic functional organization of the human lateral frontal cortex: A parcellation scheme based on resting state fMRI. The Journal of Neuroscience, 32(30), 10238-10252. doi:10.1523/JNEUROSCI.5852-11.2012.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-679E-F Version Permalink: http://hdl.handle.net/21.11116/0000-0003-C979-3
Genre: Journal Article

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 Creators:
Goulas, Alexandros1, Author              
Uylings , Harry B. M.2, Author
Stiers, Peter1, Author
Affiliations:
1Department of Neuropsychology and Psychopharmacology, Maastricht University, the Netherlands, ou_persistent22              
2Department of Anatomy and NeuroscienceVU University Medical Center, Amsterdam, the Netherlands, ou_persistent22              

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Free keywords: Functional conenctivity; In vivo parcellations; Prefrontal cortex; Neuroanatomy
 Abstract: Human and nonhuman primates exhibit flexible behavior. Functional, anatomical, and lesion studies indicate that the lateral frontal cortex (LFC) plays a pivotal role in such behavior. LFC consists of distinct subregions exhibiting distinct connectivity patterns that possibly relate to functional specializations. Inference about the border of each subregion in the human brain is performed with the aid of macroscopic landmarks and/or cytoarchitectonic parcellations extrapolated in a stereotaxic system. However, the high interindividual variability, the limited availability of cytoarchitectonic probabilistic maps, and the absence of robust functional localizers render the in vivo delineation and examination of the LFC subregions challenging. In this study, we use resting state fMRI for the in vivo parcellation of the human LFC on a subjectwise and data-driven manner. This approach succeeds in uncovering neuroanatomically realistic subregions, with potential anatomical substrates includingBA46, 44, 45, 9 and related (sub)divisions. Ventral LFC subregions exhibit different functional connectivity (FC), which can account for different contributions in the language domain, while more dorsal adjacent subregions mark a transition to visuospatial/sensorimotor networks. Dorsal LFC subregions participate in known large-scale networks obeying an external/internal information processing dichotomy. Furthermore, we traced “families” of LFC subregions organized along the dorsal–ventral and anterior–posterior axis with distinct functional networks also encompassing specialized cingulate divisions. Similarities with the connectivity of macaque candidate homologs were observed, such as the premotor affiliation of presumed BA 46. The current findings partially support dominant LFC models.

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Language(s): eng - English
 Dates: 2012-04-202011-11-232012-05-242012-07-25
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1523/JNEUROSCI.5852-11.2012
PMID: 22836258
 Degree: -

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Title: The Journal of Neuroscience
  Other : J. Neurosci.
Source Genre: Journal
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Publ. Info: Baltimore, MD : The Society
Pages: - Volume / Issue: 32 (30) Sequence Number: - Start / End Page: 10238 - 10252 Identifier: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187