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  Maintenance and manipulation of somatosensory information in ventrolateral prefrontal cortex

Spitzer, B., Goltz, D., Wacker, E., Auksztulewicz, R., & Blankenburg, F. (2014). Maintenance and manipulation of somatosensory information in ventrolateral prefrontal cortex. Human Brain Mapping, 35(5), 2412-2423. doi:10.1002/hbm.22337.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-52CC-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-7F3F-A
Genre: Journal Article

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 Creators:
Spitzer, Bernhard1, 2, Author
Goltz, Dominique3, 4, Author              
Wacker, Evelin5, Author
Auksztulewicz, Ryszard 1, 6, Author
Blankenburg, Felix1, 2, 6, Author
Affiliations:
1Dahlem Institute for Neuroimaging of Emotion, FU Berlin, Germany, ou_persistent22              
2Center for Adaptive Rationality, Max Planck Institute for Human Development, Berlin, Germany, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
4Department of Experimental Psychology and Methods, University of Leipzig, Germany, ou_persistent22              
5Charité University Medicine Berlin, Germany, ou_persistent22              
6Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              

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Free keywords: Working memory; Tactile; fMRI; Connectivity; Stimulus coding
 Abstract: Neuroimaging studies of working memory (WM) suggest that prefrontal cortex may assist sustained maintenance, but also internal manipulation, of stimulus representations in lower-level areas. A different line of research in the somatosensory domain indicates that neuronal activity in ventrolateral prefrontal cortex (VLPFC) may also represent specific memory contents in itself, however leaving open to what extent top-down control on lower-level areas is exerted, or how internal manipulation processes are implemented. We used functional imaging and connectivity analysis to study static maintenance and internal manipulation of tactile working memory contents after physically identical stimulation conditions, in human subjects. While both tasks recruited similar subareas in the inferior frontal gyrus (IFG) in VLPFC, static maintenance of the tactile information was additionally characterized by increased functional coupling between IFG and primary somatosensory cortex. Independently, during internal manipulation, a quantitative representation of the task-relevant information was evident in IFG itself, even in the absence of physical stimulation. Together, these findings demonstrate the functional diversity of activity within VLPFC according to different working memory demands, and underline the role of IFG as a core region in sensory WM processing.

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Language(s): eng - English
 Dates: 2013-04-052012-11-082013-05-102013-08-022014-05
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/hbm.22337
PMID: 23913849
Other: Epub 2013
 Degree: -

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Title: Human Brain Mapping
Source Genre: Journal
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Pages: - Volume / Issue: 35 (5) Sequence Number: - Start / End Page: 2412 - 2423 Identifier: ISSN: 1065-9471
CoNE: /journals/resource/954925601686