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  Using carbogen for calibrated fMRI at 7 Tesla: Comparison of direct and modelled estimation of the M parameter

Krieger, S., Ivanov, D., Huber, L., Roggenhofer, E., Sehm, B., Turner, R., et al. (2014). Using carbogen for calibrated fMRI at 7 Tesla: Comparison of direct and modelled estimation of the M parameter. NeuroImage, 84, 605-614. doi:10.1016/j.neuroimage.2013.09.035.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-5392-C Version Permalink: http://hdl.handle.net/21.11116/0000-0003-7F0E-1
Genre: Journal Article

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 Creators:
Krieger, Steffen1, 2, Author              
Ivanov, Dimo1, 3, Author              
Huber, Laurentius1, Author              
Roggenhofer, Elisabeth4, Author              
Sehm, Bernhard4, Author              
Turner, Robert1, Author              
Egan, Gary F.2, Author
Gauthier, Claudine1, Author              
Affiliations:
1Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634550              
2Monash Biomedical Imaging, Monash University, Melbourne, Australia, ou_persistent22              
3Maastricht Brain Imaging Centre, Maastricht University, the Netherlands, ou_persistent22              
4Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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Free keywords: Calibrated fMRI; BOLD; Hypercapnia; Hyperoxia; CMRO2; Metabolism
 Abstract: Task-evoked changes in cerebral oxygen metabolism can be measured using calibrated functional Magnetic Resonance Imaging (fMRI). This technique requires the use of breathing manipulations such as hypercapnia, hyperoxia or a combination of both to determine a calibration factor M. The M-value is usually obtained by extrapolating the BOLD signal measured during the gas manipulation to its upper theoretical physiological limit using a biophysical model. However, a recently introduced technique uses a combination of increased inspired concentrations of O2 and CO2 to saturate the BOLD signal completely. In this study, we used this BOLD saturation technique to measure M directly at 7 Tesla (T). Simultaneous carbogen-7 (7 % CO2 in 93 % O2) inhalation and visuo-motor task performance was used to elevate venous oxygen saturation in visual and motor areas close to their maximum, and the BOLD signal measured during this manipulation was used as an estimate of M. As accurate estimation of M is crucial for estimation of valid oxidative metabolism values, these directly estimated M-values were assessed and compared with M-values obtained via extrapolation modelling using the generalized calibration model (GCM) on the same dataset. Average M-values measured using both methods were 10.4±3.9 % (modelled) and 7.5±2.2 % (direct) for a visual-related ROI, and 11.3±5.2 % (modelled) and 8.1±2.6 % (direct) for a motor-related ROI. Results from this study suggest that, for the CO2 concentration used here, modelling is necessary for the accurate estimation of the M parameter. Neither gas inhalation alone, nor gas inhalation combined with a visuomotor task, was sufficient to completely saturate venous blood in most subjects. Calibrated fMRI studies should therefore rely on existing models for gas inhalation-based calibration of the BOLD signal.

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Language(s): eng - English
 Dates: 2013-09-132013-09-242014-01-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2013.09.035
PMID: 24071526
Other: Epub 2013
 Degree: -

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Title: NeuroImage
Source Genre: Journal
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Pages: - Volume / Issue: 84 Sequence Number: - Start / End Page: 605 - 614 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166