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  S100B-immunopositive astrocytes and oligodendrocytes in the hippocampus are differentially afflicted in unipolar and bipolar depression: A postmortem study

Gos, T., Schroeter, M. L., Lessel, W., Bernstein, H.-G., Dobrowolny, H., Schiltz, K., et al. (2013). S100B-immunopositive astrocytes and oligodendrocytes in the hippocampus are differentially afflicted in unipolar and bipolar depression: A postmortem study. Journal of Psychiatric Research, 47(11), 1694-1699. doi:10.1016/j.jpsychires.2013.07.005.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-567B-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-ACE8-6
Genre: Journal Article

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 Creators:
Gos, Tomasz1, 2, Author
Schroeter, Matthias L.3, 4, Author              
Lessel, Wiebke1, Author
Bernstein, Hans-Gert1, Author
Dobrowolny, Henrik1, Author
Schiltz, Kolja1, 5, Author
Bogerts, Bernhard1, 5, Author
Steiner, Johann1, 5, Author
Affiliations:
1Department of Psychiatry, Otto von Guericke University Magdeburg, Germany, ou_persistent22              
2Department of Forensic Medicine, Medical University of Gdańsk, Poland, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
4Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
5Center for Behavioral Brain Sciences , Magdeburg, Germany, ou_persistent22              

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Free keywords: Depression; Major depressive disorder; Bipolar disorder; Postmortem; Histopathology; S100B; S-100B; S100 beta
 Abstract: Background Previous studies have suggested that affective disorders are characterized by glial pathology. In this context, it has been hypothesized that elevated S100B serum and cerebrospinal fluid levels may represent a suitable surrogate marker. However, brain studies on the cellular distribution pattern of S100B in depressed patients are lacking so far. Such analyses are crucial, since S100B has been detected in various other cell types, even outside the central nervous system. Methods Therefore, we performed a first postmortem analysis on this topic in the hippocampus – which is of major importance for emotional and cognitive aspects of affective disorders. S100B-immunopositive astrocytes and oligodendrocytes were evaluated in the alveus and the CA1 pyramidal layer of patients with major depressive disorder (MDD) or bipolar I disorder (BD) compared to controls. Results As revealed by the optical disector cell-counting method, the numerical density of S100B-immunopositive astrocytes was bilaterally decreased in the CA1 pyramidal layer of MDD and BD patients compared to controls, whereas only the bipolar group showed a decreased density of S100B-immunopositive oligodendrocytes in the left alveus. These results were not confounded by gender, age, duration of disease, medication dosage, or autolysis time. Conclusions Confirming the idea of previous S100B serum and cerebrospinal fluid studies, our data suggest that S100B-immunopositive glia is dysregulated in the brains of depressed patients. These findings are in accordance with animal experiments in rodents showing a reduced astrocytic S100B-immunoreactivity in the hippocampus after pharmacological serotonin depletion (modeling depression).

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Language(s): eng - English
 Dates: 2013-06-132013-03-292013-07-052013-07-262013-11
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.jpsychires.2013.07.005
PMID: 23896207
Other: Epub 2013
 Degree: -

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Title: Journal of Psychiatric Research
Source Genre: Journal
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Publ. Info: Oxford : Pergamon
Pages: - Volume / Issue: 47 (11) Sequence Number: - Start / End Page: 1694 - 1699 Identifier: ISSN: 0022-3956
CoNE: https://pure.mpg.de/cone/journals/resource/954925417992