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  Functional dissociation of ventral frontal and dorsomedial default mode network components during resting state and emotional autobiographical recall

Bado, P., Engel, A., de Oliveira-Souza, R., Bramati, I. E., Paiva, F. F., Sato, J. R., et al. (2014). Functional dissociation of ventral frontal and dorsomedial default mode network components during resting state and emotional autobiographical recall. Human Brain Mapping, 35(7), 3302-3313. doi:10.1002/hbm.22403.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-5B2D-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-1520-1
Genre: Journal Article

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 Creators:
Bado, Patricia1, 2, Author
Engel, Annerose1, 3, Author              
de Oliveira-Souza, Ricardo1, 4, Author
Bramati, Ivanei E.1, 2, Author
Paiva, Fernando F.1, 5, Author
Sato, João R.1, 6, Author
Tovar-Moll, Fernanda1, 2, Author
Moll, Jorge1, Author
Affiliations:
1Cognitive and Behavioral Neuroscience Unit, D'Or Institute for Research and Education, Rio de Janeiro, Brazil, ou_persistent22              
2Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Brazil, ou_persistent22              
3Max Planck Research Group Music Cognition and Action, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634555              
4Gaffrée e Guinle University Hospital, Federal University of Rio de Janeiro, Brazil, ou_persistent22              
5Center for In Vivo Magnetic Resonance Spectroscopy, Institute of Physics, University of São Paulo, São Carlos, Brazil, ou_persistent22              
6Center for Mathematics, Computation, and Cognition, Federal University of ABC, Santo André, Brazil, ou_persistent22              

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Free keywords: fMRI; Default mode; Autobiographical memory; Emotion; Functional dissociation
 Abstract: Humans spend a substantial share of their lives mind-wandering. This spontaneous thinking activity usually comprises autobiographical recall, emotional, and self-referential components. While neu- roimaging studies have demonstrated that a specific brain “default mode network” (DMN) is consis- tently engaged by the “resting state” of the mind, the relative contribution of key cognitive components to DMN activity is still poorly understood. Here we used fMRI to investigate whether activity in neural components of the DMN can be differentially explained by active recall of relevant emotional autobio- graphical memories as compared with the resting state. Our study design combined emotional autobio- graphical memory, neutral memory and resting state conditions, separated by a serial subtraction control task. Shared patterns of activation in the DMN were observed in both emotional autobiographical and resting conditions, when compared with serial subtraction. Directly contrasting autobiographical and resting conditions demonstrated a striking dissociation within the DMN in that emotional autobiographi- cal retrieval led to stronger activation of the dorsomedial core regions (medial prefrontal cortex, posterior cingulate cortex), whereas the resting state condition engaged a ventral frontal network (ventral striatum, subgenual and ventral anterior cingulate cortices) in addition to the IPL. Our results reveal an as yet unreported dissociation within the DMN. Whereas the dorsomedial component can be explained by emotional autobiographical memory, the ventral frontal one is predominantly associated with the resting state proper, possibly underlying fundamental motivational mechanisms engaged during spontaneous unconstrained ideation.

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Language(s): eng - English
 Dates: 2013-08-092013-03-272013-09-042013-11-062014-07
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/hbm.22403
PMID: 25050426
Other: Epub 2013
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Title: Human Brain Mapping
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 35 (7) Sequence Number: - Start / End Page: 3302 - 3313 Identifier: ISSN: 1065-9471
CoNE: https://pure.mpg.de/cone/journals/resource/954925601686