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  Slab-selective, BOLD-corrected VASO at 7 Tesla provides measures of cerebral blood volume reactivity with high signal-to-noise ratio

Huber, L., Ivanov, D., Krieger, S., Streicher, M., Mildner, T., Poser, B., et al. (2014). Slab-selective, BOLD-corrected VASO at 7 Tesla provides measures of cerebral blood volume reactivity with high signal-to-noise ratio. Magnetic Resonance in Medicine, 72(1), 137-148. doi:10.1002/mrm.24916.

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https://doi.org/10.1002/mrm.24916 (Verlagsversion)
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 Urheber:
Huber, Laurentius1, 2, Autor           
Ivanov, Dimo2, 3, Autor           
Krieger, Steffen2, 4, Autor           
Streicher, Markus2, Autor           
Mildner, Toralf1, Autor           
Poser, Benedikt3, 5, 6, Autor
Möller, Harald E.1, Autor           
Turner, Robert2, Autor           
Affiliations:
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
2Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634550              
3Maastricht Brain Imaging Centre, Maastricht University, the Netherlands, ou_persistent22              
4Monash Biomedical Imaging, Monash University, Melbourne, Australia, ou_persistent22              
5Department of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA, ou_persistent22              
6Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands, ou_persistent22              

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Schlagwörter: Vascular space occupancy; Slab-selective VASO; Cerebral blood volume; 7 Tesla; fMRI acquisition techniques
 Zusammenfassung: Purpose

MRI methods sensitive to functional changes in cerebral blood volume (CBV) may map neural activity with better spatial specificity than standard functional MRI (fMRI) methods based on blood oxygen level dependent (BOLD) effect. The purpose of this study was to develop and investigate a vascular space occupancy (VASO) method with high sensitivity to CBV changes for use in human brain at 7 Tesla (T).
Methods

To apply 7T VASO, several high-field-specific obstacles must be overcome, e.g., low contrast-to-noise ratio (CNR) due to convergence of blood and tissue T1, increased functional BOLD signal change contamination, and radiofrequency field inhomogeneities. In the present method, CNR was increased by keeping stationary tissue magnetization in a steady-state different from flowing blood, using slice-selective saturation pulses. Interleaved acquisition of BOLD and VASO signals allowed correction for BOLD contamination.
Results

During visual stimulation, a relative CBV change of 28% ± 5% was measured, confined to gray matter in the occipital lobe with high sensitivity.
Conclusion

By carefully considering all the challenges of high-field VASO and filling behavior of the relevant vasculature, the proposed method can detect and quantify CBV changes with high CNR in human brain at 7T.

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Sprache(n): eng - English
 Datum: 2013-07-042013-03-062013-07-162013-08-202014
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1002/mrm.24916
PMID: 23963641
Anderer: Epub 2013
 Art des Abschluß: -

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Titel: Magnetic Resonance in Medicine
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 72 (1) Artikelnummer: - Start- / Endseite: 137 - 148 Identifikator: ISSN: 0740-3194
CoNE: https://pure.mpg.de/cone/journals/resource/954925538149