English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Slab-selective, BOLD-corrected VASO at 7 Tesla provides measures of cerebral blood volume reactivity with high signal-to-noise ratio

Huber, L., Ivanov, D., Krieger, S., Streicher, M., Mildner, T., Poser, B., et al. (2014). Slab-selective, BOLD-corrected VASO at 7 Tesla provides measures of cerebral blood volume reactivity with high signal-to-noise ratio. Magnetic Resonance in Medicine, 72(1), 137-148. doi:10.1002/mrm.24916.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-60CA-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-7EA0-B
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Huber, Laurentius1, 2, Author              
Ivanov, Dimo2, 3, Author              
Krieger, Steffen2, 4, Author              
Streicher, Markus2, Author              
Mildner, Toralf1, Author              
Poser, Benedikt3, 5, 6, Author
Möller, Harald E.1, Author              
Turner, Robert2, Author              
Affiliations:
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
2Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634550              
3Maastricht Brain Imaging Centre, Maastricht University, the Netherlands, ou_persistent22              
4Monash Biomedical Imaging, Monash University, Melbourne, Australia, ou_persistent22              
5Department of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA, ou_persistent22              
6Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands, ou_persistent22              

Content

show
hide
Free keywords: Vascular space occupancy; Slab-selective VASO; Cerebral blood volume; 7 Tesla; fMRI acquisition techniques
 Abstract: Purpose MRI methods sensitive to functional changes in cerebral blood volume (CBV) may map neural activity with better spatial specificity than standard functional MRI (fMRI) methods based on blood oxygen level dependent (BOLD) effect. The purpose of this study was to develop and investigate a vascular space occupancy (VASO) method with high sensitivity to CBV changes for use in human brain at 7 Tesla (T). Methods To apply 7T VASO, several high-field-specific obstacles must be overcome, e.g., low contrast-to-noise ratio (CNR) due to convergence of blood and tissue T1, increased functional BOLD signal change contamination, and radiofrequency field inhomogeneities. In the present method, CNR was increased by keeping stationary tissue magnetization in a steady-state different from flowing blood, using slice-selective saturation pulses. Interleaved acquisition of BOLD and VASO signals allowed correction for BOLD contamination. Results During visual stimulation, a relative CBV change of 28% ± 5% was measured, confined to gray matter in the occipital lobe with high sensitivity. Conclusion By carefully considering all the challenges of high-field VASO and filling behavior of the relevant vasculature, the proposed method can detect and quantify CBV changes with high CNR in human brain at 7T.

Details

show
hide
Language(s): eng - English
 Dates: 2013-07-042013-03-062013-07-162013-08-202014
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/mrm.24916
PMID: 23963641
Other: Epub 2013
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Magnetic Resonance in Medicine
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 72 (1) Sequence Number: - Start / End Page: 137 - 148 Identifier: ISSN: 0740-3194
CoNE: https://pure.mpg.de/cone/journals/resource/954925538149