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  Distinct antimicrobial peptide expression determines host species-specific bacterial associations

Franzenburg, S., Walter, J., Künzel, S., Wang, J., Baines, J. F., Bosch, T. C. G., et al. (2013). Distinct antimicrobial peptide expression determines host species-specific bacterial associations. Proceedings of the National Academy of Sciences of the United States of America, 110(39), E3730-E3738. doi:10.1073/pnas.1304960110.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-64BE-A Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0025-04E0-C
Genre: Journal Article

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 Creators:
Franzenburg, Sören, Author
Walter, Jonas, Author
Künzel, Sven1, Author              
Wang, Jun2, Author              
Baines, John F.2, Author              
Bosch, Thomas C. G., Author
Fraune, Sebastian, Author
Affiliations:
1Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445635              
2Guest Group Evolutionary Genomics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445638              

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Free keywords: host-microbe; Cnidaria; phylosymbiotic; core microbiota; holobiont
 Abstract: Animals are colonized by coevolved bacterial communities, which contribute to the host’s health. This commensal microbiota is often highly specific to its host-species, inferring strong selective pressures on the associated microbes. Several factors, including diet, mucus composition, and the immune system have been proposed as putative determinants of host-associated bacterial communities. Here we report that species-specific antimicrobial peptides account for different bacterial communities associated with closely related species of the cnidarian Hydra. Gene family extensions for potent antimicrobial peptides, the arminins, were detected in four Hydra species, with each species possessing a unique composition and expression profile of arminins. For functional analysis, we inoculated arminin-deficient and control polyps with bacterial consortia characteristic for different Hydra species and compared their selective preferences by 454 pyrosequencing of the bacterial microbiota. In contrast to control polyps, arminin-deficient polyps displayed decreased potential to select for bacterial communities resembling their native microbiota. This finding indicates that species- specific antimicrobial peptides shape species-specific bacterial associations.

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Language(s): eng - English
 Dates: 2013-03-182013-08-052013-09-032013-09-24
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1073/pnas.1304960110
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Title: Proceedings of the National Academy of Sciences of the United States of America
  Other : Proc. Natl. Acad. Sci. U. S. A.
Source Genre: Journal
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Publ. Info: National Academy of Sciences
Pages: - Volume / Issue: 110 (39) Sequence Number: - Start / End Page: E3730 - E3738 Identifier: ISSN: 0027-8424 (print)
ISSN: 1091-6490 (online)
CoNE: /journals/resource/954925427230