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  A longitudinal effects of lesions on functional networks after stroke

Ovadia-Caro, S., Villringer, K., Fiebach, J., Jungehulsing, G. J., van der Meer, E., Margulies, D. S., et al. (2013). A longitudinal effects of lesions on functional networks after stroke. Journal of Cerebral Blood Flow and Metabolism, 33(8), 1279-1285. doi:10.1038/jcbfm.2013.80.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-6969-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-9E7E-F
Genre: Journal Article

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 Creators:
Ovadia-Caro, Smadar1, 2, 3, Author              
Villringer, Kersten4, Author
Fiebach, Jochen4, Author
Jungehulsing, Gerhard Jan4, 5, Author
van der Meer, Elke1, 2, Author
Margulies, Daniel S.1, 6, Author              
Villringer, Arno1, 3, 4, Author              
Affiliations:
1Berlin School of Mind and Brain, The Mind-Brain Institute, Humboldt University, Berlin, Germany, ou_1356546              
2Institute of Psychology, Humboldt University, Berlin, Germany, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
4Center for Stroke Research, Charité University, Berlin, Germany, ou_persistent22              
5Department of Neurology, Charité University, Berlin, Germany, ou_persistent22              
6Max Planck Research Group Neuroanatomy and Connectivity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_1356546              

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Free keywords: Concordance; Dual regression; Heterogeneous lesions; Intrinsic functional connectivity; Resting-state fMRI
 Abstract: While ischemic stroke reflects focal damage determined by the affected vascular territory, clinical symptoms are often more complex and may be better explained by additional indirect effects of the focal lesion. Assumed to be structurally underpinned by anatomical connections, supporting evidence has been found using alterations in the functional connectivity of resting-state functional magnetic resonance imaging (fMRI) data in both sensorimotor and attention networks. To assess the generalizability of this phenomenon in a stroke population with heterogeneous lesions, we investigated the distal effects of lesions on a global level. Longitudinal resting-state fMRI scans were acquired at three consecutive time points, beginning during the acute phase (days 1, 7, and 90 post-stroke) in 12 patients after ischemic stroke. We found a preferential functional change in affected networks (i.e., networks containing lesions changed more during recovery when compared with unaffected networks). This change in connectivity was significantly correlated with clinical changes assessed with the National Institute of Health Stroke Scale. Our results provide evidence that the functional architecture of large-scale networks is critical to understanding the clinical effect and trajectory of post-stroke recovery.

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Language(s): eng - English
 Dates: 2013-05-292013-08
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/jcbfm.2013.80
PMID: 23715061
PMC: PMC3734780
Other: Epub 2013
 Degree: -

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Title: Journal of Cerebral Blood Flow and Metabolism
Source Genre: Journal
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Publ. Info: New York : Lippincott Williams & Wilkins
Pages: - Volume / Issue: 33 (8) Sequence Number: - Start / End Page: 1279 - 1285 Identifier: ISSN: 0271-678X
CoNE: /journals/resource/954925503202