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  The CONNECT project: Combining macro- and micro-structure

Assaf, Y., Alexander, D. C., Jones, D. K., Bizzi, A., Behrens, T. E., Clark, C. A., et al. (2013). The CONNECT project: Combining macro- and micro-structure. NeuroImage, 80, 273-282. doi:10.1016/j.neuroimage.2013.05.055.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-6995-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-840C-B
Genre: Journal Article

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 Creators:
Assaf, Yaniv, Author
Alexander, Daniel C., Author
Jones, Derek K., Author
Bizzi, Albero, Author
Behrens, Tim E.J., Author
Clark, Chris A., Author
Cohen, Yoram, Author
Dyrby, Tim B., Author
Huppi, Petra S., Author
Knösche, Thomas R.1, Author              
LeBihan, Denis, Author
Parker, Geoff J.M., Author
Poupon, Cyril, Author
Anaby, Debbie2, Author
Anwander, Alfred1, 2, Author              
Bar, Leah2, Author
Barazany, Daniel2, Author
Blumenfeld-Katzir, Tamar2, Author
De-Santis, Silvia2, Author
Duclap, Delphine2, Author
Figini, Matteo2, AuthorFischi, Elda2, AuthorGuevara, Pamela2, AuthorHubbard, Penny2, AuthorHofstetter, Shir2, AuthorJbabdi, Saad2, AuthorKunz, Nicolas2, AuthorLazeyras, Francois2, AuthorLebois, Alice2, AuthorLiptrot, Matthew G.2, AuthorLundell, Henrik2, AuthorMangin, Jean-François2, AuthorMoreno-Dominguez, David1, 2, Author              Morozov, Darya2, AuthorSchreiber, Jan1, 2, Author              Seunarine, Kiran2, AuthorNava, Simone2, AuthorPoupon, Cyril2, AuthorRiffert, Till1, 2, Author              Sasson, Efrat2, AuthorSchmitt, Benoit2, AuthorShemesh, Noam2, AuthorSotiropoulos, Stam N.2, AuthorTavora, Ido2, AuthorZhang, Hui (Gary)2, AuthorZhou, Feng-Lei2, Author more..
Affiliations:
1Methods and Development Unit Cortical Networks and Cognitive Functions, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634557              
2CONNECT Consortium (alphabetically ordered), ou_persistent22              

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 Abstract: In recent years, diffusion MRI has become an extremely important tool for studying the morphology of living brain tissue, as it provides unique insights into both its macrostructure and microstructure. Recent applications of diffusion MRI aimed to characterize the structural connectome using tractography to infer connectivity between brain regions. In parallel to the development of tractography, additional diffusion MRI based frameworks (CHARMED, AxCaliber, ActiveAx) were developed enabling the extraction of a multitude of micro-structural parameters (axon diameter distribution, mean axonal diameter and axonal density). This unique insight into both tissue microstructure and connectivity has enormous potential value in understanding the structure and organization of the brain as well as providing unique insights to abnormalities that underpin disease states. The CONNECT (Consortium Of Neuroimagers for the Non-invasive Exploration of brain Connectivity and Tracts) project aimed to combine tractography and micro-structural measures of the living human brain in order to obtain a better estimate of the connectome, while also striving to extend validation of these measurements. This paper summarizes the project and describes the perspective of using micro-structural measures to study the connectome.

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Language(s): eng - English
 Dates: 2013-05-082013-05-282013-10-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2013.05.055
PMID: 23727318
Other: Epub 2013
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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 80 Sequence Number: - Start / End Page: 273 - 282 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166